Cancer Discov. 2022 Nov 2;12(11):OF2. doi: 10.1158/2159-8290.CD-ND2022-0015.
Androgen receptor blockade may have clinical utility in treating cancers other than prostate cancer. Several mouse studies have found that antiandrogen drugs boost the efficacy of immune checkpoint inhibitors and help combat resistance to targeted agents for a variety of tumor types. Clinical trials are underway to assess AR inhibition as an adjunct to multiple forms of cancer therapy.
雄激素受体阻断可能在治疗除前列腺癌以外的癌症方面具有临床应用价值。几项小鼠研究发现,抗雄激素药物能提高免疫检查点抑制剂的疗效,并有助于对抗多种肿瘤类型的靶向药物耐药。目前正在进行临床试验,以评估 AR 抑制作为多种癌症治疗方法的辅助手段。