链格孢菌来源的红树林真菌中一种新的弯孢菌素型代谢产物单独 A
Alternarialone A, a new curvularin-type metabolite from the mangrove-derived fungus .
机构信息
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China.
出版信息
J Asian Nat Prod Res. 2023 Jun;25(6):610-616. doi: 10.1080/10286020.2022.2117168. Epub 2022 Sep 1.
Alternarialone A (), one new curvularin derivative, and two known compounds ( and ) were isolated from the crude extract of the mangrove-derived fungus . Their structures were elucidated by comprehensive spectroscopic analyses, including MS and NMR spectroscopic data. The absolute configuration of was assigned by C NMR calculations and a comparison of electronic circular dichroism (ECD) spectra. All compounds were evaluated for their antibacterial activities against . Compounds and showed antibacterial activities against G27 with MIC values of 8 and 16 µg/ml, respectively, while compound also displayed antibacterial activity against BHKS159 with the MIC value of 16 µg/ml.
从红树林来源的真菌中分离得到独一味 A (), 一个新的_curvularin 衍生物, 和两个已知化合物 ( 和 )。通过全面的光谱分析，包括 MS 和 NMR 光谱数据，阐明了它们的结构。通过 13C NMR 计算和电子圆二色性 (ECD)光谱的比较，确定了 的绝对构型。所有化合物都评估了它们对 的抗菌活性。化合物 和 对 G27 显示出抗菌活性，MIC 值分别为 8 和 16μg/ml，而化合物 也对 BHKS159 显示出抗菌活性，MIC 值为 16μg/ml。
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