老药新用：M4毒蕈碱型乙酰胆碱受体拮抗剂在气道平滑肌细胞中的偏向性GPCR激动作用 - Suppr

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New Tricks for an Old Dog: Biased GPCR Agonism of an M4 Muscarinic Acetylcholine Receptor Antagonist in Airway Smooth Muscle Cells.

作者信息

Amrani Yassine

机构信息

Department of Respiratory Sciences University of Leicester Leicester, United Kingdom.

出版信息

Am J Respir Cell Mol Biol. 2022 Nov;67(5):515-517. doi: 10.1165/rcmb.2022-0335ED.

DOI:10.1165/rcmb.2022-0335ED

PMID:36049223

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9651195/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada3/9651195/21c85528d984/rcmb.2022-0335EDf1.jpg

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本文引用的文献

PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells.PD 102807 诱导气道平滑肌细胞中 M3 mAChR 依赖性 GRK-/Arrestin 偏向信号转导。

Am J Respir Cell Mol Biol. 2022 Nov;67(5):550-561. doi: 10.1165/rcmb.2021-0320OC.

Phenotype and Functional Features of Human Telomerase Reverse Transcriptase Immortalized Human Airway Smooth Muscle Cells from Asthmatic and Non-Asthmatic Donors.哮喘和非哮喘供体来源的人端粒酶逆转录酶永生化的人气道平滑肌细胞的表型和功能特征。

Sci Rep. 2018 Jan 16;8(1):805. doi: 10.1038/s41598-017-18429-0.

Biased signalling: from simple switches to allosteric microprocessors.偏向信号传导：从简单的开关到别构微处理器。

Nat Rev Drug Discov. 2018 Apr;17(4):243-260. doi: 10.1038/nrd.2017.229. Epub 2018 Jan 5.

Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.绘制生理性G蛋白偶联受体信号通路图谱揭示了受体磷酸化在气道收缩中的作用。

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4524-9. doi: 10.1073/pnas.1521706113. Epub 2016 Apr 8.

Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling.乙酰胆碱：除了支气管收缩，在炎症和重塑中发挥作用。

Trends Pharmacol Sci. 2015 Mar;36(3):164-71. doi: 10.1016/j.tips.2014.11.005. Epub 2014 Dec 13.

Muscarinic M₃ receptors contribute to allergen-induced airway remodeling in mice.毒蕈碱型 M3 受体参与变应原诱导的小鼠气道重塑。

Am J Respir Cell Mol Biol. 2014 Apr;50(4):690-8. doi: 10.1165/rcmb.2013-0220OC.

Muscarinic receptor stimulation augments TGF-β1-induced contractile protein expression by airway smooth muscle cells.毒蕈碱型乙酰胆碱受体刺激增强转化生长因子-β1 诱导的气道平滑肌细胞收缩蛋白表达。

Am J Physiol Lung Cell Mol Physiol. 2012 Oct 1;303(7):L589-97. doi: 10.1152/ajplung.00400.2011. Epub 2012 Aug 3.

Airway smooth muscle modulation and airway hyper-responsiveness in asthma: new cellular and molecular paradigms.哮喘中的气道平滑肌调节和气道高反应性：新的细胞和分子模式。

Expert Rev Clin Immunol. 2006 May;2(3):353-64. doi: 10.1586/1744666X.2.3.353.

Targeting TNF-alpha: a novel therapeutic approach for asthma.靶向肿瘤坏死因子-α：一种治疗哮喘的新方法。

J Allergy Clin Immunol. 2008 Jan;121(1):5-10; quiz 11-2. doi: 10.1016/j.jaci.2007.10.028. Epub 2007 Nov 26.

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Curr Opin Allergy Clin Immunol. 2002 Feb;2(1):39-45. doi: 10.1097/00130832-200202000-00007.

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