血清神经丝蛋白与水通道蛋白 4 抗体阳性视神经脊髓炎谱系疾病的视网膜结构损伤相关。
Serum glial fibrillary acidic protein correlates with retinal structural damage in aquaporin-4 antibody positive neuromyelitis optica spectrum disorder.
机构信息
Experimental and Clinical Research Center, A Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Experimental and Clinical Research Center, A Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
出版信息
Mult Scler Relat Disord. 2022 Nov;67:104100. doi: 10.1016/j.msard.2022.104100. Epub 2022 Aug 9.
BACKGROUND
Aquaporin-4 immunoglobulin-G positive (AQP4-IgG) neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy associated with optic neuritis (ON). Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an oligodendrocytopathy with a similar phenotype. Serum glial fibrillary acidic protein (sGFAP), an astrocyte-derived protein, is associated with disease severity in AQP4-IgG NMOSD. Serum neurofilament light (sNfL) indicates neuroaxonal damage. The objective was to investigate the association of sGFAP and sNfL with subclinical afferent visual system damage in clinically stable AQP4-IgG NMOSD and MOGAD patients.
METHODS
In this cross-sectional study, clinically stable patients with AQP4-IgG NMOSD (N = 33) and MOGAD (N = 16), as diseased controls, underwent sGFAP and sNfL measurements by single molecule array, retinal optical coherence tomography and visually evoked potentials.
RESULTS
Higher sGFAP concentrations were associated with thinner ganglion cell-inner plexiform layer (β (95% confidence interval (CI)) = -0.75 (-1.23 to -0.27), p = 0.007) and shallower fovea (average pit depth: β (95%CI) = -0.59 (-0.63 to -0.55), p = 0.020) in NMOSD non-ON eyes. Participants with pathological P100 latency had higher sGFAP (median [interquartile range]: 131.32 [81.10-179.34] vs. 89.50 [53.46-121.91] pg/ml, p = 0.024). In MOGAD, sGFAP was not associated with retinal structural or visual functional measures.
CONCLUSIONS
The association of sGFAP with structural and functional markers of afferent visual system damage in absence of ON suggests that sGFAP may be a sensitive biomarker for chronic disease severity in clinically stable AQP4-IgG NMOSD.
背景
水通道蛋白 4 免疫球蛋白 G 阳性（AQP4-IgG）视神经脊髓炎谱系障碍（NMOSD）是一种与视神经炎（ON）相关的自身免疫性星形胶质细胞病。髓鞘少突胶质细胞糖蛋白抗体相关性疾病（MOGAD）是一种具有相似表型的少突胶质细胞病。血清神经丝轻链（sNfL）是一种神经轴突损伤的标志物。本研究旨在探讨在临床稳定的 AQP4-IgG NMOSD 和 MOGAD 患者中，血清胶质纤维酸性蛋白（sGFAP）和 sNfL 与亚临床传入性视觉系统损伤的相关性。
方法
在这项横断面研究中，33 例临床稳定的 AQP4-IgG NMOSD 患者（N=33）和 16 例 MOGAD 患者（N=16）作为疾病对照组，接受了 sGFAP 和 sNfL 的单分子阵列、视网膜光学相干断层扫描和视觉诱发电位测量。
结果
sGFAP 浓度较高与 NMOSD 非 ON 眼的神经节细胞-内丛状层变薄（β（95%置信区间（CI））=-0.75（-1.23 至-0.27），p=0.007）和黄斑区变浅（平均凹坑深度：β（95%CI）=-0.59（-0.63 至-0.55），p=0.020）相关。P100 潜伏期异常的患者 sGFAP 水平较高（中位数[四分位间距]：131.32[81.10-179.34]比 89.50[53.46-121.91]pg/ml，p=0.024）。在 MOGAD 中，sGFAP 与视网膜结构或视觉功能测量值无关。
结论
在无 ON 的情况下，sGFAP 与传入性视觉系统损伤的结构和功能标志物相关，这表明 sGFAP 可能是临床稳定的 AQP4-IgG NMOSD 慢性疾病严重程度的敏感生物标志物。
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