Pediatric Neurology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Pediatric Neurology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Pediatr Neurol. 2022 Nov;136:15-19. doi: 10.1016/j.pediatrneurol.2022.06.016. Epub 2022 Jun 28.
Several retrospective studies on pediatric epilepsy reported positive effects of cannabidiol-enriched artisanal cannabis oil and pure cannabidiol oil on seizure reduction.
This is a retrospective study of children and adolescents with refractory epilepsy caused by various etiologies who were treated with artisanal cannabis oil during January 2014 to June 2019, with at least one year follow-up.
Of 114 patients, 84 (73.3%) reported some improvement in seizure frequency at some point during treatment. Fifty-one (59%) of the 86 patients who continued treatment for at least one year showed >50% improvement in seizure frequency. Seizure etiology, seizure type, and patients' age and sex were not found to be associated with the response to cannabidiol-enriched cannabis oil. Side effects were minor, and positive effects beyond seizure reduction were noted.
Artisanal cannabidiol-enriched cannabis may be an effective and safe long-term treatment for refractory epilepsy.
几项针对儿科癫痫的回顾性研究报告称，富含大麻二酚的手工大麻油和纯大麻二酚油对减少癫痫发作有积极影响。
这是一项回顾性研究，纳入了在 2014 年 1 月至 2019 年 6 月期间接受手工大麻油治疗的、由各种病因引起的难治性癫痫的儿童和青少年患者，所有患者均至少随访了 1 年。
114 例患者中，有 84 例（73.3%）在治疗过程中的某个时间点报告癫痫发作频率有所改善。86 例至少持续治疗 1 年的患者中有 51 例（59%）癫痫发作频率改善超过 50%。癫痫病因、癫痫类型以及患者的年龄和性别与对富含大麻二酚的大麻油的反应无相关性。副作用较小，且观察到了除减少癫痫发作以外的积极效果。
手工制作的富含大麻二酚的大麻可能是治疗难治性癫痫的一种有效且安全的长期治疗方法。
