Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Lab for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
Khushal Khan Khattak University, Karak, Khyber Pakhtunkhwa, Pakistan.
Comput Biol Med. 2022 Oct;149:106000. doi: 10.1016/j.compbiomed.2022.106000. Epub 2022 Aug 18.
Head and neck squamous cell carcinoma (HNSCC) is a frequent malignant tumor of the head and neck with a dismal survival probability due to relapse and metastasis. S100As have been identified as being involved in the tumor procession of various cancer types. However, the expressions of S100As in HNSCC and their prognostic relevance are unknown. Bioinfromatics analysis was conducted to identify the prognostic value and function of S100As in HNSCC patients. In the study, we found that high mRNA expression levels of S100A3, S100A4, S100A7A, S100A9, and low mRNA expression levels of S100A1, S100A10 were related with a good overall survival in HNSCC patients. Importantly, the prognosis model suggested that S100A10 may have a certain impact on the development of HNSCC. Moreover, single-cell RNA sequencing analysis clarified that the specific functions of S100A10 had positive regulatory effects on metastasis, blood vessel generation, EMT, hypoxia, and invasion. Our findings implied that S100A10 might be a new prognostic biomarker for HNSCC, and played a role in promoting the occurrence, and development of HNSCC.
头颈部鳞状细胞癌（HNSCC）是一种常见的头颈部恶性肿瘤，由于复发和转移，其生存概率较差。S100A 蛋白已被确定参与多种癌症类型的肿瘤发生过程。然而，S100A 在 HNSCC 中的表达及其与预后的相关性尚不清楚。本研究通过生物信息学分析，鉴定 S100A 在 HNSCC 患者中的预后价值和功能。在研究中，我们发现 S100A3、S100A4、S100A7A、S100A9 的高 mRNA 表达水平和 S100A1、S100A10 的低 mRNA 表达水平与 HNSCC 患者的总生存预后良好相关。重要的是，预后模型表明 S100A10 可能对 HNSCC 的发展有一定影响。此外，单细胞 RNA 测序分析阐明了 S100A10 的特定功能对转移、血管生成、EMT、缺氧和侵袭有积极的调节作用。我们的研究结果表明，S100A10 可能是 HNSCC 的一个新的预后生物标志物，并在促进 HNSCC 的发生和发展中发挥作用。
