药物性肝损伤。

Drug-Induced Liver Injury.

机构信息

Adult Gerontology, Acute Care Nurse Practitioner Program, Louisiana Health Science Center - New Orleans, 1900 Gravier Street, Suite 156, New Orleans, LA 70112, USA.

出版信息

Crit Care Nurs Clin North Am. 2022 Sep;34(3):267-275. doi: 10.1016/j.cnc.2022.04.007. Epub 2022 Jul 20.

DOI:10.1016/j.cnc.2022.04.007

PMID:36049846

Abstract

Drug-induced liver injury (DILI) is a spectrum of liver injuries that can be classified by phenotype and injury patterns. Some injury patterns can be predicted in a number of drugs that are commonly used in practice, but idiosyncratic reactions are unpredictable and are not dose related. There are diagnostic criteria to assist in the classification of DILI phenotype as well as therapeutic interventions to ensure maximal support to the patient affected with DILI to include referral for liver transplantation in some cases.

摘要

药物性肝损伤（DILI）是一种可以通过表型和损伤模式进行分类的肝脏损伤谱。一些损伤模式可以在一些在临床上常用的药物中预测，但特发性反应是不可预测的，与剂量无关。有诊断标准可以帮助对 DILI 表型进行分类，还有治疗干预措施可以确保对 DILI 患者提供最大的支持，包括在某些情况下转介进行肝移植。