Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
Department of Health Sciences, Hanyang University College of Medicine, Seoul, Republic of Korea.
Am J Prev Med. 2022 Dec;63(6):894-903. doi: 10.1016/j.amepre.2022.07.001. Epub 2022 Aug 30.
This study investigated the association between longitudinal smoking habit changes and cancer risk in a cohort of Korean women.
Study population included women aged ≥40 years who underwent 2 biennial cancer screenings (2009-2010 and 2011-2012) and were followed up until 2020. This analysis was conducted in 2021. On the basis of changes in smoking habits, participants were grouped into sustained nonsmokers, sustained quitters, new quitters, relapsers, smoking initiators, and sustained smokers. Outcomes included incident cancer cases, smoking-related cancers, and specific cancer sites.
Of 3,051,946 women, the mean age was 54.8 years, and the median follow-up was 8.9 years. Compared with sustained nonsmokers, other groups had a significantly increased risk of cancer and smoking-related cancers: sustained quitters (adjusted hazard ratio=1.05; 95% CI=1.01, 1.09), new quitters (adjusted hazard ratio=1.12; 95% CI=1.07, 1.17), and sustained smokers (adjusted hazard ratio=1.14; 95% CI=1.09, 1.19). A significantly increased risk of lung, stomach, liver, and pancreas cancers was found in sustained smokers and new quitters. Relapsers/smoking initiators showed a higher risk of liver, lung, and breast cancer than sustained nonsmokers, but the strength of their corresponding adjusted hazard ratio was generally lower than that of sustained smokers. The hazard ratio of cancer risk was 0.92 (95% CI=0.87, 0.97) among sustained quitters and 0.97 (95% CI=0.91, 1.03) among new quitters relative to that among sustained smokers.
This study found a significant association between changes in smoking behavior and cancer risk. These findings suggest that smoking cessation is critical for cancer prevention in women.
本研究调查了韩国女性队列中纵向吸烟习惯变化与癌症风险之间的关联。
研究人群包括年龄≥40 岁的女性，她们接受了两次每两年一次的癌症筛查（2009-2010 年和 2011-2012 年），并随访至 2020 年。本分析于 2021 年进行。基于吸烟习惯的变化，参与者被分为持续不吸烟者、持续戒烟者、新戒烟者、复吸者、新吸烟者和持续吸烟者。结果包括新发癌症病例、与吸烟相关的癌症和特定癌症部位。
在 3051946 名女性中，平均年龄为 54.8 岁，中位随访时间为 8.9 年。与持续不吸烟者相比，其他组发生癌症和与吸烟相关的癌症的风险显著增加：持续戒烟者（调整后的危险比=1.05；95%置信区间=1.01，1.09），新戒烟者（调整后的危险比=1.12；95%置信区间=1.07，1.17）和持续吸烟者（调整后的危险比=1.14；95%置信区间=1.09，1.19）。持续吸烟者和新戒烟者发生肺癌、胃癌、肝癌和胰腺癌的风险显著增加。复吸者/新吸烟者发生肝癌、肺癌和乳腺癌的风险高于持续不吸烟者，但相应调整后的危险比强度通常低于持续吸烟者。与持续吸烟者相比，持续戒烟者的癌症风险比为 0.92（95%置信区间=0.87，0.97），新戒烟者的癌症风险比为 0.97（95%置信区间=0.91，1.03）。
本研究发现吸烟行为变化与癌症风险之间存在显著关联。这些发现表明，戒烟对女性预防癌症至关重要。
