镰状细胞病女性所生孩子的发育障碍：来自波士顿出生队列的报告。
Developmental disorders in children born to women with sickle cell disease: A report from the Boston Birth Cohort.
作者信息
Brucato Martha, Lance Eboni, Lanzkron Sophie, Wang Xiaobin, Pecker Lydia H
机构信息
Department of Internal Medicine/Pediatrics Johns Hopkins University School of Medicine Baltimore Maryland USA.
Department of Neurology and Developmental Medicine Kennedy Krieger Institute, Baltimore Maryland USA.
出版信息
EJHaem. 2022 Jun 8;3(3):894-898. doi: 10.1002/jha2.478. eCollection 2022 Aug.
Abstract
Children exposed to maternal sickle cell disease (SCD) have many theoretical risks for developmental disorders, but little is known about long-term outcomes for these children. We used the Boston Birth Cohort to compare developmental outcomes between children exposed to maternal SCD and matched, unexposed controls. Children with exposure to maternal SCD had increased risk of attention deficit hyperactivity disorder (OR 5.12, 95% CI 1.36-19.19, = 0.02) and obesity (OR 2.74, 95% CI 1.10-6.87, = 0.03). In utero and/or environmental exposures may help explain these findings. Further studies of outcomes of children born to women with SCD are needed.
摘要
患有镰状细胞病（SCD）的母亲所生子女面临发育障碍的诸多理论风险，但对这些孩子的长期结局却知之甚少。我们利用波士顿出生队列比较了患有母亲SCD的儿童与匹配的未暴露对照组儿童的发育结局。患有母亲SCD的儿童患注意力缺陷多动障碍的风险增加（比值比5.12，95%可信区间1.36 - 19.19，P = 0.02）和肥胖（比值比2.74，95%可信区间1.10 - 6.87，P = 0.03）。宫内和/或环境暴露可能有助于解释这些发现。需要对患有SCD的女性所生孩子的结局进行进一步研究。
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