Sherman J W, Conte J E
Am J Med. 1987 Jul;83(1):137-8. doi: 10.1016/0002-9343(87)90508-0.
Empiric treatment of serious Salmonella infections has been complicated by the emergence of strains resistant to multiple antimicrobial agents, including ampicillin, chloramphenicol, and trimethoprim/sulfamethoxazole. Recent reports suggest that the third-generation cephalosporins may be effective therapy for Salmonella infections. This report describes a case of antibiotic-resistant Salmonella heidelberg prosthetic hip infection successfully treated with prosthesis removal and once-daily ceftriaxone. Tube dilution sensitivity testing of the organism demonstrated minimal inhibitory and minimal bactericidal concentrations of 0.12 microgram/ml. Serum bactericidal activity, 30 minutes after infusion, was inhibitory and bactericidal at 1:512. It is concluded that the favorable preliminary results reported in the literature and the outcome in this patient suggest that the third-generation cephalosporins may be effective therapy for Salmonella infections and should undergo clinical trials.
对严重沙门氏菌感染进行经验性治疗因对多种抗菌药物耐药的菌株出现而变得复杂，这些抗菌药物包括氨苄西林、氯霉素和甲氧苄啶/磺胺甲恶唑。最近的报告表明，第三代头孢菌素可能是治疗沙门氏菌感染的有效疗法。本报告描述了一例对多种抗生素耐药的海德堡沙门氏菌人工髋关节感染病例，通过移除假体并每日一次使用头孢曲松成功治愈。对该菌株进行的试管稀释敏感性试验显示，最低抑菌浓度和最低杀菌浓度为0.12微克/毫升。输液30分钟后的血清杀菌活性在1:512时具有抑菌和杀菌作用。得出的结论是，文献中报道的良好初步结果以及该患者的治疗结果表明，第三代头孢菌素可能是治疗沙门氏菌感染的有效疗法，应进行临床试验。
