急性单纯性下尿路感染患者血清CRP和PCT水平变化及双冬胶囊治疗效果评价

Changes in Serum CRP and PCT Levels in Patients with Acute Simple Lower Urinary Tract Infection and Evaluation of the Efficacy of Treatment with Shuangdong Capsules.

作者信息

Tang Yachun, Zhou Qun

机构信息

The Affiliated Nanhua Hospital, Department of Urology, Hengyang Medical School, Universitity of South China, Hengyang 421002, Hunan, China.

出版信息

Emerg Med Int. 2022 Aug 23;2022:9750237. doi: 10.1155/2022/9750237. eCollection 2022.

DOI:10.1155/2022/9750237

PMID:36052218

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9427299/

Abstract

OBJECTIVE

The aim of this study is to investigate the changes and significance of serum C-reactive protein (CRP) and procalcitonin (PCT) levels in patients with acute simple lower urinary tract infection (ALUTI) and to analyze the efficacy of treatment with Shuangdong capsules, so as to provide a basis for the rational clinical application of drugs.

METHODS

92 patients with ALUTI (observation group) were randomly divided into 46 cases each in group A and group B. Group A was treated with basic anti-infective drugs, while group B was treated with Shuangdong capsules, and the duration of treatment in both groups was 14 days. The curative effect of the two groups was analyzed, and the changes in serum PCT and CRP levels were compared before and after treatment and compared with 40 healthy people in the control group.

RESULTS

The serum PCT and CRP levels, the number of urinary leukocyte count (LEU), and the number of urinary bacterial count (BACT) were significantly higher in Group A and Group B than in the healthy control group before treatment ( < 0.05). After treatment, the total clinical efficiency of patients in group B (97.83%) was significantly higher than that in group A (78.26%) ( < 0.05). The serum PCT and CRP levels, the number of urinary LEU, and the number of urinary BACT decreased in both groups after treatment compared with those before treatment, and all of them were significantly lower in group B than in group A ( < 0.05). The area under the curve (AUC) values of serum PCT and CRP levels for the diagnosis of acute simple lower urinary tract infection were 0.747 (95% CI 0.633-0.860) and 0.926 (95% CI 0.870∼0.982), both with high sensitivity and specificity.

CONCLUSION

The Shuangdong capsule combined with conventional antibacterial drugs has better clinical efficacy in the treatment of acute simple lower urinary tract infection; serum CRP and PCT levels in patients with acute simple lower urinary tract infection can be used as indicators for diagnosis and efficacy determination of the infection.

摘要

目的

本研究旨在探讨急性单纯性下尿路感染（ALUTI）患者血清C反应蛋白（CRP）和降钙素原（PCT）水平的变化及意义，并分析双冬胶囊的治疗效果，为临床合理用药提供依据。

方法

将92例ALUTI患者（观察组）随机分为A组和B组，每组46例。A组采用基础抗感染药物治疗，B组采用双冬胶囊治疗，两组治疗疗程均为14天。分析两组的疗效，比较治疗前后血清PCT和CRP水平的变化，并与对照组40例健康人进行比较。

结果

治疗前，A组和B组的血清PCT和CRP水平、尿白细胞计数（LEU）及尿细菌计数（BACT）均显著高于健康对照组（<0.05）。治疗后，B组患者的总临床有效率（97.83%）显著高于A组（78.26%）（<0.05）。与治疗前相比，两组治疗后血清PCT和CRP水平、尿LEU及尿BACT均降低，且B组均显著低于A组（<0.05）。血清PCT和CRP水平诊断急性单纯性下尿路感染的曲线下面积（AUC）值分别为0.747（95%CI 0.633 - 0.860）和0.926（95%CI 0.870∼0.982），均具有较高的敏感性和特异性。