子宫内膜癌中内分泌途径与上皮-间质转化的交叉点
Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer.
作者信息
Gelissen Julia H, Huang Gloria S
机构信息
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, CT, United States.
出版信息
Front Oncol. 2022 Aug 16;12:914405. doi: 10.3389/fonc.2022.914405. eCollection 2022.
Abstract
The epithelial mesenchymal transition (EMT) is the process by which cancer cells of epithelial origin, including endometrial cancer, acquire a mesenchymal phenotype with enhanced migratory and invasive capacity, to facilitate metastasis. The regulation of EMT is tissue-specific, and in endometrial cancer, endocrine signaling pathways serve as critical regulators of EMT. The intersections of endocrine signaling and EMT highlight potential avenues for therapeutic intervention to target cancer metastasis with the aim of reduced mortality.
摘要
上皮-间质转化（EMT）是一个过程，起源于上皮的癌细胞，包括子宫内膜癌，通过这个过程获得具有增强迁移和侵袭能力的间质表型，以促进转移。EMT的调控具有组织特异性，在子宫内膜癌中，内分泌信号通路是EMT的关键调节因子。内分泌信号与EMT的交叉点突出了潜在的治疗干预途径，旨在通过靶向癌症转移来降低死亡率。
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