Bertrand M, Lickrish G M, Colgan T J
Am J Obstet Gynecol. 1987 Jul;157(1):21-5. doi: 10.1016/s0002-9378(87)80338-1.
The anatomic distribution of cervical adenocarcinoma in situ was ascertained in 23 cases of adenocarcinoma in situ, 10 of which also had "early" invasive adenocarcinoma. The adenocarcinoma in situ involved both surface and gland epithelia in all cases, involved a variable number of quadrants, involved glands beneath the transformation zone in about two thirds of cases, was multifocal only occasionally, extended up the endocervical canal for a variable distance (up to 30 mm), and was associated with squamous dysplasia in about half of cases. From this topographic outline of adenocarcinoma in situ, it is recommended that if cervical conization is chosen as conservative therapy for adenocarcinoma in situ the "cone" be cylindrical in shape, to include the transformation zone and deep glands, and extend at least 25 mm up the endocervical canal.
对23例宫颈原位腺癌的解剖分布情况进行了确定，其中10例还伴有“早期”浸润性腺癌。所有病例的原位腺癌均累及表面和腺上皮，累及象限数量不一，约三分之二的病例累及转化区下方的腺体，仅偶尔为多灶性，沿宫颈管向上延伸的距离不一（可达30毫米），约半数病例伴有鳞状上皮发育异常。根据原位腺癌的这种形态学概述，建议如果选择宫颈锥切术作为原位腺癌的保守治疗方法，“锥切”应呈圆柱形，以包括转化区和深部腺体，并沿宫颈管向上至少延伸25毫米。
