• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肝素结合蛋白对重症 COVID-19 肺炎患者死亡率的预测价值。

Prognostic value of heparin-binding protein for mortality in severe COVID-19 pneumonia.

机构信息

Department of Emergency, University of Health Sciences, Beyhekim Training & Research Hospital, Konya, 42060, Turkey.

Department of Emergency, Numune State Hospital, Konya, Turkey.

出版信息

Biomark Med. 2022 Sep;16(13):981-991. doi: 10.2217/bmm-2022-0265. Epub 2022 Sep 2.

DOI:10.2217/bmm-2022-0265
PMID:36052658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9443788/
Abstract

The study investigated heparin-binding protein (HBP) levels in patients with severe COVID-19 pneumonia and their relation to prognosis. A total of 134 patients with serious COVID-19 pneumonia were prospectively analyzed. HBP levels were statistically compared between both the patient and healthy control groups and within the patient group itself. HBP was defined to be significantly higher in the patient group compared with the control group. There was a statistically significant distinction between the patients who survived and those who died with regard to HBP levels. When the cutoff value of HBP was >13.47, sensitivity (89.8%), specificity (74.1%) had area under the curve values of 0.806 (p < 0.001). HBP level may be used for prognosis prediction of patients with COVID-19.

摘要

本研究调查了严重 COVID-19 肺炎患者肝素结合蛋白 (HBP) 水平及其与预后的关系。前瞻性分析了 134 例严重 COVID-19 肺炎患者。统计比较了患者组和健康对照组以及患者组自身的 HBP 水平。与对照组相比，患者组 HBP 水平显著升高。HBP 水平在存活患者和死亡患者之间存在统计学差异。当 HBP 的截断值>13.47 时，其灵敏度（89.8%）、特异性（74.1%）的曲线下面积值为 0.806（p<0.001）。HBP 水平可用于预测 COVID-19 患者的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/503834b86cbf/figure5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/882cf1d3320f/figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/72546d0c6cd2/figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/15d5c1a6cb26/figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/ab8d03caa954/figure4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/503834b86cbf/figure5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/882cf1d3320f/figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/72546d0c6cd2/figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/15d5c1a6cb26/figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/ab8d03caa954/figure4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc53/9443788/503834b86cbf/figure5.jpg

相似文献

1
Prognostic value of heparin-binding protein for mortality in severe COVID-19 pneumonia.肝素结合蛋白对重症 COVID-19 肺炎患者死亡率的预测价值。
Biomark Med. 2022 Sep;16(13):981-991. doi: 10.2217/bmm-2022-0265. Epub 2022 Sep 2.
2
Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19).肝素结合蛋白与白细胞介素-6在 SARS-CoV-2（COVID-19）所致肺炎早期预测呼吸衰竭和死亡中的整合作用。
Eur J Clin Microbiol Infect Dis. 2021 Jul;40(7):1405-1412. doi: 10.1007/s10096-020-04145-7. Epub 2021 Jan 29.
3
Prediction of Clinical Severity of COVID-19 Using a Combination of Heparin-Binding Protein, Interleukin-6, and C-Reactive Protein: A Retrospective Study.利用肝素结合蛋白、白细胞介素-6 和 C 反应蛋白联合预测 COVID-19 的临床严重程度：一项回顾性研究。
Clin Respir J. 2024 Aug;18(8):e70003. doi: 10.1111/crj.70003.
4
[Value of heparin-binding protein in the diagnosis of severe adenovirus pneumonia in children].[肝素结合蛋白在儿童重症腺病毒肺炎诊断中的价值]
Zhongguo Dang Dai Er Ke Za Zhi. 2022;24(9):1014-1019. doi: 10.7499/j.issn.1008-8830.2203157.
5
HEPARIN-BINDING PROTEIN LEVELS PREDICT UNFAVORABLE OUTCOME IN COVID-19 PNEUMONIA: A POST HOC ANALYSIS OF THE SAVE TRIAL.肝素结合蛋白水平预测 COVID-19 肺炎不良结局：SAVE 试验的事后分析。
Shock. 2024 Mar 1;61(3):395-399. doi: 10.1097/SHK.0000000000002315. Epub 2024 Jan 19.
6
[Mechanism of heparin-binding protein increasing vascular permeability in early burn].[肝素结合蛋白增加早期烧伤血管通透性的机制]
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2020 Mar;32(3):330-335. doi: 10.3760/cma.j.cn121430-20200123-00248.
7
[Diagnostic value of HBP, PCT combined with APACHE Ⅱ score respectively in ventilator-associated pneumonia].[降钙素原、高敏降钙素原联合急性生理学与慢性健康状况评分Ⅱ分别对呼吸机相关性肺炎的诊断价值]
Zhonghua Yi Xue Za Zhi. 2019 Jun 11;99(22):1698-1702. doi: 10.3760/cma.j.issn.0376-2491.2019.22.003.
8
Serum Heparin-Binding Protein as a Potential Biomarker to Distinguish Adult-Onset Still's Disease From Sepsis.血清肝素结合蛋白作为鉴别成人Still 病与脓毒症的潜在生物标志物。
Front Immunol. 2021 Mar 31;12:654811. doi: 10.3389/fimmu.2021.654811. eCollection 2021.
9
Heparin binding protein in severe COVID-19-A prospective observational cohort study.严重 COVID-19 患者中肝素结合蛋白：一项前瞻性观察性队列研究。
PLoS One. 2021 Apr 6;16(4):e0249570. doi: 10.1371/journal.pone.0249570. eCollection 2021.
10
Significance of Heparin-Binding Protein and D-dimers in the Early Diagnosis of Spontaneous Bacterial Peritonitis.肝素结合蛋白和 D-二聚体在自发性细菌性腹膜炎早期诊断中的意义。
Mediators Inflamm. 2018 Sep 30;2018:1969108. doi: 10.1155/2018/1969108. eCollection 2018.

引用本文的文献

1
Longitudinal Analysis of Traditional Inflammatory Markers (IL-6, CRP) Juxtaposed With Heparin-Binding Protein (HBP) and Serum Amyloid A Protein Component (SAA) During Acute Infection and Convalescence From COVID-19 Infection in the Context of Initial Viral Load and Markers of Tissue Destruction.在急性感染期间以及从 COVID-19 感染康复过程中，结合初始病毒载量和组织破坏标志物，对传统炎症标志物（白细胞介素-6、C 反应蛋白）与肝素结合蛋白（HBP）和血清淀粉样蛋白 A 蛋白成分（SAA）进行纵向分析。
J Immunol Res. 2025 Jun 28;2025:8881752. doi: 10.1155/jimr/8881752. eCollection 2025.
2
Heparin-binding Protein as a Diagnostic and Prognostic Marker of Infections: A Systematic Review and Meta-analysis.肝素结合蛋白作为感染的诊断和预后标志物：一项系统评价和荟萃分析
Mediterr J Hematol Infect Dis. 2025 May 1;17(1):e2025029. doi: 10.4084/MJHID.2025.029. eCollection 2025.
3
The diagnostic and prognostic value of heparin-binding protein in cerebrospinal fluid for patients with intracranial infections.脑脊液中肝素结合蛋白对颅内感染患者的诊断和预后价值
Eur J Med Res. 2024 Dec 18;29(1):579. doi: 10.1186/s40001-024-02183-x.
4
Prediction of Clinical Severity of COVID-19 Using a Combination of Heparin-Binding Protein, Interleukin-6, and C-Reactive Protein: A Retrospective Study.利用肝素结合蛋白、白细胞介素-6 和 C 反应蛋白联合预测 COVID-19 的临床严重程度：一项回顾性研究。
Clin Respir J. 2024 Aug;18(8):e70003. doi: 10.1111/crj.70003.
5
Diagnostic and prognostic value of heparin-binding protein in sepsis: A systematic review and meta-analysis.肝素结合蛋白在脓毒症中的诊断和预后价值：系统评价和荟萃分析。
Medicine (Baltimore). 2024 Jun 21;103(25):e38525. doi: 10.1097/MD.0000000000038525.