Intensive Care Unit, Shanghai Construction Group Hospital, Shanghai, 200433, China.
Intensive Care Unit, Yantai Qi Shan Hospital, Yantai, Shandong, 264001, China.
Biomark Med. 2022 Sep;16(13):1005-1017. doi: 10.2217/bmm-2022-0390. Epub 2022 Sep 2.
To clarify the role of polymorphisms rs4986790 and rs4986791 in with susceptibility to neonatal sepsis. To evaluate the possible correlation of polymorphisms rs4986790 and rs4986791 with sepsis risk, odds ratios (ORs) were calculated. The heterogeneity was evaluated by χ-based Q-test. For rs4986790, ORs were 1.36 (95% CI: 1.05-1.79, p = 0.017) and 1.84 (95% CI: 0.04-7.9, p = 0.410) under AG+GG versus AA and G vs A models, respectively. For rs4986791, ORs were 2.22 (95% CI: 1.25-3.94, p = 0.006) and 2.20 (95% CI: 1.26-3.85, p = 0.005) under CT+TT versus CC and of T versus C models, respectively. The rs4986790 and rs4986791 polymorphisms in could influence the sepsis susceptibility in neonates.
为了阐明 rs4986790 和 rs4986791 多态性在新生儿败血症易感性中的作用。为了评估 rs4986790 和 rs4986791 多态性与败血症风险的可能相关性，计算了比值比（ORs）。通过基于 χ 的 Q 检验评估异质性。对于 rs4986790，AG+GG 与 AA 相比，ORs 分别为 1.36（95%CI：1.05-1.79，p=0.017）和 1.84（95%CI：0.04-7.9，p=0.410）。对于 rs4986791，CT+TT 与 CC 相比，ORs 分别为 2.22（95%CI：1.25-3.94，p=0.006）和 2.20（95%CI：1.26-3.85，p=0.005）。T 与 C 相比。 中的 rs4986790 和 rs4986791 多态性可能影响新生儿的败血症易感性。
