Animal Diseases and Public Health Engineering Research Center of Henan Province, Luoyang Polytechnic, Luoyang, China.
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
Anim Biotechnol. 2023 Dec;34(7):2778-2792. doi: 10.1080/10495398.2022.2118130. Epub 2022 Sep 2.
CircRNAs are a novel type of closed circular molecules formed through a covalent bond lacking a 5'cap and 3' end tail, which mainly arise from mRNA precursor. They are widely distributed in plants and animals and are characterized by stable structure, high conservativeness in cells or tissues, and showed the expression specificity at different stages of development in different tissues. CircRNAs have been gradually attracted wide attention with the development of RNA sequencing, which become a new research hotspot in the field of RNA. CircRNAs play an important role in gene expression regulation. Presently, the related circRNAs research in the regulation of animal muscle development is still at the initial stage. In this review, the formation, properties, biological functions of circRNAs were summarized. The recent research progresses of circRNAs in skeletal muscle growth and development from economic animals including livestock, poultry and fishes were introduced. Finally, we proposed a prospective for further studies of circRNAs in muscle development, and we hope our research could provide new ideas, some theoretical supports and helps for new molecular genetic markers exploitation and animal genetic breeding in future.
CircRNAs 是一种新型的闭合环状分子，通过共价键形成，缺乏 5'帽和 3'端尾巴，主要来源于 mRNA 前体。它们广泛存在于动植物中，具有稳定的结构、在细胞或组织中高度保守性，并在不同组织的不同发育阶段表现出表达特异性。随着 RNA 测序技术的发展，CircRNAs 逐渐引起了广泛的关注，成为 RNA 领域的一个新的研究热点。CircRNAs 在基因表达调控中发挥着重要作用。目前，动物肌肉发育调控中相关的 CircRNAs 研究仍处于起步阶段。本文综述了 CircRNAs 的形成、特性、生物学功能。介绍了经济动物（包括家畜、家禽和鱼类）中 CircRNAs 在骨骼肌生长和发育中的最新研究进展。最后，我们对 CircRNAs 在肌肉发育中的进一步研究提出了展望，希望我们的研究能为未来的肌肉发育新分子遗传标记的开发和动物遗传育种提供新的思路、一些理论支持和帮助。
