Operative Unit of Infectious Diseases, "V. Fazzi" Hospital, Lecce, Italy.
Laboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, Faculty of Sciences, University of Salento, Lecce, Italy.
Curr Med Res Opin. 2022 Dec;38(12):2119-2121. doi: 10.1080/03007995.2022.2120689. Epub 2022 Sep 9.
is a Gram-positive bacteria and etiological agent of listeriosis. It has the ability to colonize the intestinal lumen and cross the intestinal, blood-brain, and placental barriers, leading to invasive listeriosis responsible for septicemia and meningitis in subjects at risk such as patients with diabetes mellitus, the elderly, and immunocompromised individuals and, for maternal-neonatal infection in pregnant women. We report a rare case of septicemia and meningitis complicated by fungemia on a patient with a history of type 2 diabetes mellitus, hypothyroidism, hypertension, chronic kidney failure, chronic ischemic vascular encephalopathy, and atrial fibrillation. Although adequate therapy was rapidly started with an initial partial clinical improvement, the patient suddenly experienced clinical worsening concomitantly with septicemia resulting in a fatal outcome. To our knowledge, this is the first described case of an invasive infection complicated by sepsis. We hypothesize that concomitant Candida infection may play a significant role in the pathogenesis and virulence of .
李斯特菌是一种革兰氏阳性细菌，也是李斯特菌病的病原体。它具有在肠道腔中定植的能力，并能穿过肠道、血脑和胎盘屏障，导致侵袭性李斯特菌病，使糖尿病、老年人和免疫功能低下等高危人群发生败血症和脑膜炎，也会导致孕妇的母婴感染。我们报告了一例罕见的病例，一名 2 型糖尿病、甲状腺功能减退、高血压、慢性肾衰竭、慢性缺血性血管性脑病和心房颤动病史的患者并发败血症和脑膜炎，以及合并真菌血症。尽管迅速开始了适当的治疗，初始时部分临床情况有所改善，但患者突然出现临床恶化，同时发生败血症，导致致命后果。据我们所知，这是首例描述的侵袭性 感染并发败血症的病例。我们假设同时发生的念珠菌感染可能在李斯特菌的发病机制和毒力中起重要作用。
