载银([2]轮烷)中穿梭运动和催化的平行变构抑制
Parallel Allosteric Inhibition of Shuttling Motion and Catalysis in a Silver(I)-loaded [2]Rotaxane.
机构信息
Center of Micro- and Nanochemistry and (Bio)Technology, Universität Siegen, Organische Chemie I, Adolf-Reichwein-Str. 2, D-57068 Siegen, Germany.
出版信息
Org Lett. 2022 Sep 16;24(36):6609-6613. doi: 10.1021/acs.orglett.2c02609. Epub 2022 Sep 2.
A dynamic silver(I)-loaded [2]rotaxane shuttle ( = 135 kHz) was converted allosterically into a conformationally restricted [2]rotaxane due to the creation of a bulky imine in the center of the axle component. Only the dynamic silver(I)-loaded [2]rotaxane was able to catalyze a 6--cyclization reaction, whereas the static one was catalytically quiet. The mechanism of catalyst deactivation was elucidated.
一种动态的银（I）负载[2]轮烷穿梭物（= 135 kHz）通过在轴组件的中心形成一个庞大的亚胺，被别构转化成一个构象受限的[2]轮烷。只有动态的银（I）负载[2]轮烷能够催化 6-环化反应，而静态的则没有催化活性。阐明了催化剂失活的机制。
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