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基因组模拟:用于育种计划随机模拟的快速 R 函数。

genomicSimulation: fast R functions for stochastic simulation of breeding programs.

机构信息

Centre for Animal Science, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, 4072 QLD, Australia.

Department of Grapevine Breeding, Hochschule Geisenheim University, Geisenheim 65366, Germany.

出版信息

G3 (Bethesda). 2022 Sep 30;12(10). doi: 10.1093/g3journal/jkac216.

Abstract

Simulation tools are key to designing and optimizing breeding programs that are multiyear, high-effort endeavors. Tools that operate on real genotypes and integrate easily with other analysis software can guide users toward crossing decisions that best balance genetic gains and genetic diversity required to maintain gains in the future. Here, we present genomicSimulation, a fast and flexible tool for the stochastic simulation of crossing and selection based on real genotypes. It is fully written in C for high execution speeds, has minimal dependencies, and is available as an R package for the integration with R's broad range of analysis and visualization tools. Comparisons of a simulated recreation of a breeding program to a real data set demonstrate the simulated offspring from the tool correctly show key population features, such as genomic relationships and approximate linkage disequilibrium patterns. Both versions of genomicSimulation are freely available on GitHub: The R package version at https://github.com/vllrs/genomicSimulation/ and the C library version at https://github.com/vllrs/genomicSimulationC/.

摘要

模拟工具是设计和优化多年、高投入的育种计划的关键。能够处理真实基因型并与其他分析软件轻松集成的工具,可以指导用户做出最佳的杂交决策,在平衡遗传增益的同时,保持未来的遗传多样性。在这里,我们介绍了 genomicSimulation,这是一种基于真实基因型的快速灵活的杂交和选择随机模拟工具。它完全用 C 编写,以实现高执行速度,依赖项最少,并作为 R 包提供,可与 R 广泛的分析和可视化工具集成。模拟的育种计划重现与真实数据集的比较表明,该工具模拟的后代正确地显示了关键的群体特征,如基因组关系和近似连锁不平衡模式。genomicSimulation 的两个版本都可以在 GitHub 上免费获得:R 包版本位于 https://github.com/vllrs/genomicSimulation/,C 库版本位于 https://github.com/vllrs/genomicSimulationC/。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d96b/9526041/0d2501036db4/jkac216f1.jpg

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