Lee R W, Lancaster L D, Buckley D, Goldman S
Am J Physiol. 1987 Jul;253(1 Pt 2):H126-32. doi: 10.1152/ajpheart.1987.253.1.H126.
To determine whether changes in the venous circulation were responsible for preload-afterload mismatch with angiotensin, we examined the changes in the heart and the peripheral circulation in six splenectomized dogs after ganglion blockade during an angiotensin infusion to increase mean aortic pressure 25 and then 50%. The peripheral circulation was evaluated by measuring mean circulatory filling pressure (MCFP), arterial compliance, and venous compliance. A 25% increase in mean aortic pressure increased MCFP from 6.2 +/- 0.3 to 7.6 +/- 0.3 mmHg (P less than 0.001) but did not change cardiac output, heart rate, or stroke volume. Systemic vascular resistance increased (P less than 0.01) from 0.50 +/- 0.02 to 0.59 +/- 0.03 mmHg X min X kg X ml-1. Arterial and venous compliances decreased (P less than 0.01) from 0.08 +/- 0.03 to 0.06 +/- 0.03 ml X mmHg-1 X kg-1 and from 2.1 +/- 0.1 to 1.6 +/- 0.1 ml X mmHg-1 X kg-1, respectively. A 50% elevation in mean aortic pressure increased MCFP from 7.1 +/- 0.4 to 9.5 +/- 0.9 mmHg (P less than 0.001) but did not change heart rate. At this level of aortic pressure, cardiac output and stroke volume decreased (P less than 0.01) 12 and 19%, respectively, whereas systemic vascular resistance increased (P less than 0.001) from 0.48 +/- 0.03 to 0.83 +/- 0.05 mmHg X min X kg X ml-1. Arterial and venous compliances decreased (P less than 0.01) from 0.08 +/- 0.01 to 0.05 +/- 0.01 ml X mmHg-1 X kg-1 and from 2.1 +/- 0.1 to 1.4 +/- 0.1 ml X mmHg-1 X kg-1, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
为了确定静脉循环的改变是否是导致血管紧张素引起的前负荷-后负荷失匹配的原因，我们对6只脾切除犬在神经节阻断后进行血管紧张素输注，使平均主动脉压分别升高25%和50%，观察心脏和外周循环的变化。通过测量平均循环充盈压（MCFP）、动脉顺应性和静脉顺应性来评估外周循环。平均主动脉压升高25%时，MCFP从6.2±0.3 mmHg升高至7.6±0.3 mmHg（P<0.001），但心输出量、心率或每搏量未改变。全身血管阻力从0.50±0.02 mmHg·min·kg·ml⁻¹升高至0.59±0.03 mmHg·min·kg·ml⁻¹（P<0.01）。动脉和静脉顺应性分别从0.08±0.03 ml·mmHg⁻¹·kg⁻¹降至0.06±0.03 ml·mmHg⁻¹·kg⁻¹和从2.1±0.1 ml·mmHg⁻¹·kg⁻¹降至1.6±0.1 ml·mmHg⁻¹·kg⁻¹（P<0.01）。平均主动脉压升高50%时，MCFP从7.1±0.4 mmHg升高至9.5±0.9 mmHg（P<0.001），心率未改变。在此主动脉压水平，心输出量和每搏量分别下降12%和19%（P<0.01），而全身血管阻力从0.48±0.03 mmHg·min·kg·ml⁻¹升高至0.83±0.05 mmHg·min·kg·ml⁻¹（P<0.001）。动脉和静脉顺应性分别从0.08±0.01 ml·mmHg⁻¹·kg⁻¹降至0.05±0.01 ml·mmHg⁻¹·kg⁻¹和从2.1±0.1 ml·mmHg⁻¹·kg⁻¹降至1.4±0.1 ml·mmHg⁻¹·kg⁻¹（P<0.01）。（摘要截断于250字）
