Milanesi Fernanda C, Greggianin Bruna F, Dos Santos Gabriela O, Toniazzo Mirian P, Weidlich Patricia, Gerchman Fernando, Oppermann Rui V
Post-graduate Program in Dentistry: Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Department of Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
J Clin Periodontol. 2023 Jan;50(1):11-21. doi: 10.1111/jcpe.13717. Epub 2022 Aug 27.
To assess the effect of periodontal treatment on HbA1c and diagnostic parameters of patients with metabolic syndrome (MetS).
One hundred and fifty-eight patients with MetS and moderate and severe periodontitis were included. They were randomized into a test group (n = 79), which received non-surgical periodontal treatment, and a control group (n = 79), which received no treatment. Medical treatment was delivered to both groups. Clinical periodontal, anthropometric and serological parameters were assessed at baseline, 3 and 6 months. The main outcome was glycated haemoglobin (HbA1c) levels, and the secondary outcomes were changes in the MetS parameters, C-reactive protein (CRP) and HOMA indexes.
Significant reductions in all periodontal parameters were observed in the test group, compared with the control group, at 3 and 6 months (p < .001). HbA1c levels, MetS parameters, CRP and HOMA indexes showed no significant differences between the test group and the control group at 3 and 6 months.
Periodontal treatment led to a substantial reduction in periodontal inflammation, although there was no significant effect on the parameters used for MetS diagnosis in patients with early diagnosed and well-controlled MetS.
评估牙周治疗对代谢综合征（MetS）患者糖化血红蛋白（HbA1c）及诊断参数的影响。
纳入158例患有MetS且患有中度和重度牙周炎的患者。他们被随机分为试验组（n = 79），接受非手术牙周治疗；以及对照组（n = 79），不接受治疗。两组均接受药物治疗。在基线、3个月和6个月时评估临床牙周、人体测量和血清学参数。主要结局为糖化血红蛋白（HbA1c）水平，次要结局为MetS参数、C反应蛋白（CRP）和HOMA指数的变化。
与对照组相比，试验组在3个月和6个月时所有牙周参数均显著降低（p < 0.001）。试验组和对照组在3个月和6个月时HbA1c水平、MetS参数、CRP和HOMA指数均无显著差异。
牙周治疗使牙周炎症大幅减轻，尽管对早期诊断且病情控制良好的MetS患者的MetS诊断参数没有显著影响。
