Department of Otolaryngology, Head and Neck Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia.
Department of Otolaryngology, Head and Neck Surgery, John Hunter Hospital, Newcastle, New South Wales, Australia.
Laryngoscope. 2023 Jul;133(7):1667-1672. doi: 10.1002/lary.30362. Epub 2022 Aug 26.
This study evaluates and compares the prognostic significance of F-fluoro-deoxyglucose-positron emission tomography ( F-FDG PET) volumetric parameters in human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC).
A retrospective review of all patients treated for OPSCC with curative intent between 2012 and 2018 was performed. Volumetric parameters analyzed included the maximum standardized uptake value (SUV ), SUV , metabolic tumor volume (MTV), and total lesion glycolysis (TLG) in both the primary tumor and nodal metastases. Prognostic significance was determined using Cox proportional hazards models for disease-free survival (DFS) and overall survival (OS).
Primary tumor MTV and TLG significantly correlated with both DFS and OS however the commonly reported SUV was not found to be predictive. Nodal measures of SUV , MTV, and TLG were not significant predictors of survival outcomes.
A higher burden of metabolically active primary tumor as measured on volumetric F-FDG PET parameters is associated with poorer DFS and OS. This improved prognostication may be used to counsel patients and select those appropriate for treatment de-escalation in the future.
3 Laryngoscope, 133:1667-1672, 2023.
本研究评估并比较了氟-18 氟代脱氧葡萄糖正电子发射断层扫描（ F-FDG PET）容积参数在人乳头瘤病毒相关口咽鳞状细胞癌（OPSCC）中的预后意义。
对 2012 年至 2018 年间接受 OPSCC 根治性治疗的所有患者进行了回顾性分析。分析的容积参数包括原发肿瘤和淋巴结转移灶的最大标准化摄取值（SUV ）、SUV 、代谢肿瘤体积（MTV）和总肿瘤糖酵解（TLG）。使用 Cox 比例风险模型确定无病生存率（DFS）和总生存率（OS）的预后意义。
原发肿瘤 MTV 和 TLG 与 DFS 和 OS 显著相关，但常见的 SUV 并未被发现具有预测性。淋巴结的 SUV 、MTV 和 TLG 测量值不是生存结局的显著预测因子。
在 F-FDG PET 容积参数上测量到的代谢活跃的原发肿瘤负担更高与较差的 DFS 和 OS 相关。这种改善的预后预测可能用于为患者提供咨询，并选择未来适合治疗降级的患者。
3 级 Laryngoscope, 133:1667-1672, 2023.
