Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, China.
Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, China.
Head Neck. 2022 Dec;44(12):2649-2659. doi: 10.1002/hed.27172. Epub 2022 Aug 20.
Nomograms specifically used to predict the prognosis of ascending type nasopharyngeal carcinoma (NPC) have not been constructed.
Data of ascending type (T3-4N0-1M0) NPC from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015 were extracted.
Altogether 862 patients with ascending type NPC were enrolled, including 603 in training cohort and 259 in validation cohort. Age, marital status, pathology, grade, tumor size, T classification, and chemotherapy were the independent prognostic factors for overall survival (OS). Age, marital status, pathology, grade, and chemotherapy were the independent prognostic factors for cancer-specific survival (CSS). In training cohort, the concordance index of the OS and CSS nomograms were 0.694 (95% confidence interval [CI], 0.677-0.711) and 0.678 (95%CI, 0.659-0.697), respectively, while those in validation cohort were 0.740 (95%CI, 0.715-0.765) and 0.708 (95%CI, 0.679-0.737), separately.
The as-constructed nomograms for ascending type NPC could provide accurate prognostic predictions of OS and CSS.
尚未构建专门用于预测升型鼻咽癌（NPC）预后的列线图。
从 2004 年至 2015 年的监测、流行病学和最终结果（SEER）数据库中提取升型（T3-4N0-1M0）NPC 的数据。
共纳入 862 例升型 NPC 患者，其中训练队列 603 例，验证队列 259 例。年龄、婚姻状况、病理、分级、肿瘤大小、T 分类和化疗是总生存（OS）的独立预后因素。年龄、婚姻状况、病理、分级和化疗是癌症特异性生存（CSS）的独立预后因素。在训练队列中，OS 和 CSS 列线图的一致性指数分别为 0.694（95%置信区间[CI]，0.677-0.711）和 0.678（95%CI，0.659-0.697），验证队列中分别为 0.740（95%CI，0.715-0.765）和 0.708（95%CI，0.679-0.737）。
所构建的升型 NPC 列线图可以对 OS 和 CSS 进行准确的预后预测。
