Department of Thoracic Surgery, University Center for Thoracic Diseases, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.
Department of Thoracic Surgery, ViDia Kliniken Karlsruhe, Karlsruhe, Germany.
Thorac Cancer. 2022 Oct;13(20):2861-2866. doi: 10.1111/1759-7714.14630. Epub 2022 Aug 30.
The aim of this study was to evaluate predictors for long-term overall survival (OS) in patients with stage I non-small cell lung cancer (NSCLC).
All patients undergoing complete resection by lobectomy for stage I NSCLC between October 2012 and December 2015 at a single center were included. Univariable and multivariable Cox regression analyses were performed to identify prognostic factors.
A total of 92 patients were included. Univariable and multivariable Cox regression analyses revealed preoperative neutrophil to lymphocyte ratio (NLR, p = 0.005), preoperative diffusion capacity of the lungs for carbon monoxide (DLCO, p = 0.010) and forced expiratory volume in 1 second (FEV1, p = 0.041) as well as male gender (p = 0.026) as independent prognostic factors for OS. Combining the calculated cutoff values for FEV1 (<73.0%) and NLR (>3.49) into one parameter resulted in a highly significant difference in survival times when stratified by this variable.
Recently, much emphasis has been put on the prognostic importance of blood biomarkers in NSCLC. In our study, NLR was an independent factor for OS, as were baseline characteristics such as DLCO, FEV1, and gender. Further studies on the association of biomarkers for systemic inflammation and lung function parameters with respect to patient survival are warranted.
本研究旨在评估 I 期非小细胞肺癌（NSCLC）患者的长期总生存期（OS）的预测因素。
本研究纳入了 2012 年 10 月至 2015 年 12 月在一家中心接受完全肺叶切除术治疗的所有 I 期 NSCLC 患者。采用单变量和多变量 Cox 回归分析确定预后因素。
共纳入 92 例患者。单变量和多变量 Cox 回归分析显示，术前中性粒细胞与淋巴细胞比值（NLR，p=0.005）、术前一氧化碳弥散量（DLCO，p=0.010）和 1 秒用力呼气量（FEV1，p=0.041）以及男性（p=0.026）是 OS 的独立预后因素。将计算出的 FEV1（<73.0%）和 NLR（>3.49）的临界值组合成一个参数，根据该变量分层时，生存时间有显著差异。
最近，人们非常重视 NSCLC 中血液生物标志物的预后重要性。在本研究中，NLR 是 OS 的独立因素，DLCO、FEV1 和性别等基线特征也是 OS 的独立因素。需要进一步研究全身炎症标志物和肺功能参数与患者生存之间的关系。
