Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Geriatric Research and Education and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA.
Sci Immunol. 2022 Sep 2;7(75):eade5698. doi: 10.1126/sciimmunol.ade5698.
Adipocyte derived SPARC induces pro-inflammatory changes to macrophages, leading to aging that can be reduced by caloric restriction.
脂肪细胞衍生的 SPARC 诱导巨噬细胞发生促炎变化，导致衰老，而热量限制可减少这种衰老。
