Electrical and Software Engineering, University of Calgary, Calgary, Alberta, Canada.
Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
J Biophotonics. 2022 Nov;15(11):e202200076. doi: 10.1002/jbio.202200076. Epub 2022 Aug 21.
Deep brain stimulation (DBS) is a revolutionary treatment for movement disorders. Measuring DBS-induced hemodynamic responses may be useful for surgical guidance of DBS electrode implantation as well as to study the mechanism and assess therapeutic effects of DBS. In this study, we evaluated the performance of a single fiber spectroscopic (SFS) system for measuring hemodynamic response in different cortical layers in a DBS animal model. We showed that SFS is capable of measuring minute relative changes in oxygen saturation and blood volume fraction in-vivo at a sampling rate of 22-33 Hz. During stimulation, blood volume fraction increased, while oxygen saturation showed both increases and decreases at different cortical depths across animals. In addition, we showed the potential of using SFS for measuring other physiological parameters, for example, heart rate, and respiratory rate.
脑深部电刺激（DBS）是一种治疗运动障碍的革命性方法。测量 DBS 诱导的血液动力学反应可能有助于 DBS 电极植入的手术指导，并研究 DBS 的机制和评估治疗效果。在这项研究中，我们评估了单纤维光谱（SFS）系统在 DBS 动物模型中测量不同皮层层血液动力学反应的性能。我们表明，SFS 能够以 22-33 Hz 的采样率测量体内氧饱和度和血容量分数的微小相对变化。在刺激过程中，血容量分数增加，而氧饱和度在不同动物的不同皮层深度表现出增加和减少。此外，我们还展示了 SFS 测量其他生理参数的潜力，例如心率和呼吸率。
