Department of Cardiology, Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, China.
J Clin Ultrasound. 2023 Jan;51(1):31-35. doi: 10.1002/jcu.23290. Epub 2022 Aug 24.
To analyze the correlation between catecholamines and echocardiographic parameters in patients with pheochromocytoma and paraganglioma (PPGL).
Sixty-six patients who underwent surgical resection of pathologically proven PPGL from January 2016 to June 2019 were examined. Echocardiographic parameters were compared between patients with elevated catecholamine concentrations and those with normal concentrations.
The percentage of patients with elevation of any catecholamine (NE, DA, or E, and their metabolites) did not significantly differ between patients with normal and abnormal left ventricular ejection function (LVEF) or diastolic function (LVDF). E wave deceleration time (EDT) was significantly lower in patients with elevation of any catecholamine than in those with normal concentrations (p = 0.024). EDT was significantly lower in patients with elevated NE and its metabolites than in patients with normal NE concentration (p = 0.004). After adjusting for gender and age, EDT was significantly negatively correlated with elevated NE and its metabolites in regression analysis (B-value, -39.853; p = 0.023) and correlation analysis (r = -0.349; p = 0.004).
NE and its metabolites may have an impact on left ventricular diastolic function, which can be reflected by EDT. EDT was negatively correlated with elevated NE and its metabolites.
分析嗜铬细胞瘤和副神经节瘤（PPGL）患者儿茶酚胺与超声心动图参数的相关性。
检查了 2016 年 1 月至 2019 年 6 月期间经手术切除病理证实的 66 例 PPGL 患者。比较了儿茶酚胺浓度升高患者与浓度正常患者的超声心动图参数。
在左心室射血功能（LVEF）或舒张功能（LVDF）正常和异常的患者中，任何儿茶酚胺（NE、DA 或 E 及其代谢产物）升高的患者比例无显著差异。与儿茶酚胺浓度正常的患者相比，任何儿茶酚胺升高的患者的 E 波减速时间（EDT）明显降低（p=0.024）。与 NE 及其代谢产物浓度正常的患者相比，NE 及其代谢产物升高的患者的 EDT 明显降低（p=0.004）。在校正性别和年龄后，回归分析（B 值，-39.853；p=0.023）和相关性分析（r=-0.349；p=0.004）均显示 EDT 与升高的 NE 和其代谢产物显著负相关。
NE 和其代谢产物可能对左心室舒张功能产生影响，EDT 可反映这一影响。EDT 与升高的 NE 和其代谢产物呈负相关。
