Guerrero Ruiz Graciela Del Pilar
Hospital Militar Central, Universidad Militar Nueva Granada, Bogotá, Colombia. E-mail:
Medicina (B Aires). 2022 Aug 30;82 Suppl 3:13-18.
The International League Against Epilepsy (ILAE) recently socialized the proposed classification for epileptic syndromes of neonatal onset and up to the first 2 years of age, dividing them into self-limited epileptic syndromes and epileptic and developmental encephalopathies (DEEs). In this review we will focus on DEEs, defined as disorders in which there is developmental impairment related to both the underlying aetiology independent of epileptiform activity and epileptic encephalopathy. These include early infantile epileptic encephalopathy or Ohtahara syndrome and early myoclonic encephalopathy in the neonatal period, now grouped under the name of epileptic and early childhood developmental encephalopathies (EIDEE). Infantile epileptic spasms syndrome, childhood epilepsy with migratory crises and Dravet syndrome are part of the infant-onset encephalopathies. The importance of early recognition of epileptic encephalopathies lies not only in the control of epileptic seizures, but also in stopping deterioration by trying to change the course of the disease. It is essential to know the etiology, avoiding medications that can exacerbate seizures and worsen the course, applying precision m edicine as well as identifying candidate patients for early epilepsy surgery.
国际抗癫痫联盟（ILAE）最近公布了针对新生儿期至2岁儿童癫痫综合征的拟议分类，将其分为自限性癫痫综合征以及癫痫与发育性脑病（DEE）。在本综述中，我们将重点关注DEE，其定义为一种疾病，其中存在与潜在病因（独立于癫痫样活动）以及癫痫性脑病相关的发育障碍。这些疾病包括早期婴儿癫痫性脑病或大田原综合征以及新生儿期的早期肌阵挛性脑病，现在它们被归为癫痫与儿童早期发育性脑病（EIDEE）这一名称之下。婴儿痉挛症综合征、伴有游走性发作的儿童癫痫以及德雷维特综合征都属于婴儿期起病的脑病。早期识别癫痫性脑病的重要性不仅在于控制癫痫发作，还在于通过尝试改变疾病进程来阻止病情恶化。了解病因、避免使用可能加重发作并恶化病情的药物、应用精准医学以及确定早期癫痫手术的候选患者至关重要。
