Ceska Gynekol. 2022;87(4):261-268. doi: 10.48095/cccg2022261.
Amniotic fluid embolism (AFE) is a rare and often fatal obstetric complication, characterized by sudden cardiovascular collapse, dyspnea, seizures, mental alteration or coma and laboratory and clinically dia-gnosed disseminated intravascular coagulation (DIC). Patients reaction is typically biphasic with initial pulmonary hypertension and right ventricular failure, followed by left ventricular failure during or immediately right after labor. Early recognition of AFE is critical to a successful survival. Aggressive shock management is needed in collaboration with an anesthesiologist. Several aspects of the condition remain a controversy. This review critically examines, from the best available evidence, the current knowledge regarding the epidemiology, pathophysiology, dia-gnosis, and available treatment of AFE. This dia-gnosis still determines perinatal morbidity and mortality and potential permanent neurological symptoms for surviving patients.
羊水栓塞（AFE）是一种罕见且常常致命的产科并发症，其特征为突然发生心血管崩溃、呼吸困难、癫痫发作、精神改变或昏迷，以及实验室和临床诊断的弥散性血管内凝血（DIC）。患者的反应通常呈双相性，最初表现为肺动脉高压和右心室衰竭，随后在分娩期间或分娩后立即出现左心室衰竭。早期识别 AFE 对于成功存活至关重要。需要与麻醉师合作进行积极的休克管理。该病症的几个方面仍存在争议。本综述从现有最佳证据出发，批判性地评估了 AFE 的流行病学、病理生理学、诊断和现有治疗方法。该诊断仍然决定了围产期发病率和死亡率，以及幸存患者潜在的永久性神经症状。
