Radiation Oncology Department, CHU de Brest, Brest, France; LaTim, Iserm, UMR 1101, université de Brest, 29200 Brest, France.
Radiation Oncology Department, CHU de Brest, Brest, France; Radiation Oncology Department, CHIC de Quimper, 29000 Quimper, France.
Cancer Radiother. 2022 Oct;26(6-7):905-910. doi: 10.1016/j.canrad.2022.07.008. Epub 2022 Aug 31.
Brachytherapy (BT), a type of focal cancer radiation therapy, delivers a highly focused dose of radiation to localized tumors, sparing surrounding normal tissue. Brachytherapy has been used to treat gynecologic malignancies, particularly cervical cancer, for over 100 years. From the first gynecologic brachytherapy treatments in the early 20th century to the modern era, significant transformations have taken place, largely due to advances in technology. The development of high-dose-rate sources, remote afterloaders, new applicators, and three-dimensional image guidance has increased tumor dose and, consequently, local control and survival, reinforcing brachytherapy's role as an integral component of gynecologic cancer treatment. Current research efforts involving biomarker research, integration of new imaging modalities, radiosensitizing therapies are aimed at further personalizing the dose delivered in BT to further improve local control and reduce treatment's related toxicities.
近距离放射治疗（Brachytherapy，BT）是一种针对局部肿瘤的高聚焦辐射疗法，可使周围正常组织免受辐射。BT 已被用于治疗妇科恶性肿瘤，特别是宫颈癌，已有 100 多年的历史。从 20 世纪初的第一次妇科近距离放射治疗到现代，已经发生了重大变革，这主要得益于技术的进步。高剂量率源、远程后装机、新型施源器和三维图像引导的发展提高了肿瘤剂量，从而提高了局部控制率和生存率，巩固了 BT 在妇科癌症治疗中的重要作用。目前的研究工作涉及生物标志物研究、新的成像方式的整合、放射增敏治疗，旨在进一步实现 BT 中剂量的个体化，以进一步提高局部控制率，降低治疗相关毒性。
