Mehta Nikhil, Pai Rohan
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM\\\'s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai- 400056, India.
Pharm Nanotechnol. 2022 Sep 2. doi: 10.2174/2211738510666220902150449.
In recent years, nanotechnology has gained much attention from scientists and significant advances in therapeutic potential. Nano-delivery systems have emerged as an effective way in order to improve the therapeutic properties of drugs including solubility, stability, prolongation of half-life as well as promoting the accumulation of drug at the target site. The nanoparticles have also been incorporated into various conventional drug delivery systems. This review study aims to introduce the amalgamation of nanoparticles into drug carriers. To overcome the limitations of single nanoparticles such as toxicity, high instability, rapid drug release as well as limited drug loading capacity, a multi-component system is developed. Liposomes, microparticles, nanofibers, dendrimers etc., are promising drug carriers, having some limitations that can be minimized, and the compilation of nanoparticles synergizes the properties. The amalgamated nanocarriers are used for the diagnostic purpose as well as treatment of various chronic diseases. It also increases the solubility of hydrophobic drugs. However, each system has its advantages and disadvantages based on its physicochemical properties, efficacy, and other parameters. This review details the past and present state of development for the fusion of nanoparticles within drug carriers and from which we identify future research works needed for the same.
近年来，纳米技术已引起科学家们的广泛关注，并在治疗潜力方面取得了重大进展。纳米递送系统已成为一种有效的方式，以改善药物的治疗特性，包括溶解度、稳定性、半衰期延长以及促进药物在靶部位的积累。纳米颗粒也已被纳入各种传统药物递送系统中。本综述旨在介绍纳米颗粒与药物载体的融合。为了克服单一纳米颗粒的局限性，如毒性、高不稳定性、药物快速释放以及有限的载药量，开发了一种多组分系统。脂质体、微粒、纳米纤维、树枝状大分子等是有前景的药物载体，它们存在一些可以最小化的局限性，而纳米颗粒的组合可增强这些特性。融合后的纳米载体可用于诊断目的以及治疗各种慢性疾病。它还能提高疏水性药物的溶解度。然而，每个系统基于其物理化学性质、功效和其他参数都有其优缺点。本综述详细介绍了纳米颗粒与药物载体融合的过去和当前发展状况，并据此确定了未来所需的研究工作。
