Department of Rheumatology, Hôspital Charles-Nicolle, Tunis, Tunisia.
Curr Rheumatol Rev. 2023;19(2):214-221. doi: 10.2174/1573397118666220902100151.
Fibromyalgia may be associated to Spondyloarthritis with which it shares some common symptoms such as sleep disorders, fatigue and diffuse pain, leading to diagnostic and treatment dilemmas.
We aimed to determine the prevalence of fibromyalgia in axial spondyloarthritis and to determine how fibromyalgia might influence the assessments of disease activity and how it might impact treatment.
An observational cross-sectional study was conducted. The study included 100 patients with axial spondyloarthritis according to the Assessment of SpondyloArthritis international Society criteria. Fibromyalgia was diagnosed based on the 2010 American College of Rheumatology criteria. Demographics, disease characteristics, activity parameters and treatment were compared between patients with and without fibromyalgia. Patients were recruited from the hospitalization unit and the outpatient clinic of rheumatology.
The mean age of patients was 44.65 ± 13.13 years, with a sex ratio equal to 2. The prevalence of fibromyalgia was 20%. Fibromyalgia associated factors were advanced age and a late age at the onset of axial spondyloarthritis. Disease activity parameters such as global pain VAS, BASDAI, ASDAS-ESR, ASDAS-CRP, BASFI and BAS-G as well as MASES and BASMI were significantly higher in the presence of FM. Doses of paracetamol were significantly higher among FM+ patients. Also, treatment duration of the current anti-TNF alpha agent was significantly shorter among FM+ patients.
Our study showed that fibromyalgia was associated with axial spondyloarthritis in 20% of patients. Its presence was associated with higher disease activity parameters and negative impact on the treatment.
纤维肌痛症可能与脊柱关节炎有关，两者有一些共同的症状，如睡眠障碍、疲劳和弥漫性疼痛，这导致了诊断和治疗方面的困境。
我们旨在确定纤维肌痛症在中轴型脊柱关节炎中的患病率，并确定纤维肌痛症可能如何影响疾病活动的评估，以及它可能如何影响治疗。
进行了一项观察性横断面研究。该研究纳入了 100 名符合评估脊柱关节炎国际协会标准的中轴型脊柱关节炎患者。根据 2010 年美国风湿病学会标准诊断纤维肌痛症。比较了有和没有纤维肌痛症的患者的人口统计学、疾病特征、活动参数和治疗情况。患者从风湿病住院病房和门诊招募。
患者的平均年龄为 44.65 ± 13.13 岁，性别比例为 2。纤维肌痛症的患病率为 20%。纤维肌痛症的相关因素是年龄较大和中轴型脊柱关节炎发病较晚。存在纤维肌痛症时，疾病活动参数如全球疼痛 VAS、BASDAI、ASDAS-ESR、ASDAS-CRP、BASFI 和 BAS-G 以及 MASES 和 BASMI 均显著升高。FM+患者的扑热息痛剂量明显更高。此外，FM+患者当前抗 TNF-α 药物的治疗持续时间明显更短。
我们的研究表明，纤维肌痛症在 20%的中轴型脊柱关节炎患者中与该病相关。其存在与更高的疾病活动参数和对治疗的负面影响有关。
