Ford D J, Raj P P
Anesth Analg. 1987 Aug;66(8):719-22.
The responses of peripheral nerves less than 6 hr after and 2 weeks after exposure to 2-chloroprocaine (2-CP) and bisulfite (BS) were studied in cats using electrophysiologic techniques and by light and electron microscopy. Three percent 2-CP with 0.07% or 0.2% BS was not toxic to peripheral nerves. Three percent 2-CP with 1.2% BS and 1.2% BS (pH 2.8) alone had an acute effect on the peripheral nerves but no chronic effect. Ten percent BS (pH 2.8) caused Wallerian degeneration. However, at pH 4.8, no chronic toxicity was observed. Using conductivity measurements, it was shown that 2-CP and BS, when mixed, form an ion pair in solution that lowers the effective concentration of BS.
利用电生理技术以及光学和电子显微镜，对猫在暴露于2-氯普鲁卡因（2-CP）和亚硫酸氢盐（BS）后6小时内及2周后的外周神经反应进行了研究。含0.07%或0.2% BS的3% 2-CP对外周神经无毒。含1.2% BS的3% 2-CP和单独的1.2% BS（pH 2.8）对外周神经有急性影响，但无慢性影响。10% BS（pH 2.8）导致沃勒变性。然而，在pH 4.8时，未观察到慢性毒性。通过电导率测量表明，2-CP和BS混合时在溶液中形成离子对，从而降低了BS的有效浓度。
