Biomedical and Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, Republic of Korea.
Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, Republic of Korea.
Macromol Rapid Commun. 2022 Nov;43(21):e2200423. doi: 10.1002/marc.202200423. Epub 2022 Sep 15.
CO -triggered in situ hydrogels is developed from waterborne poly(ε-caprolactone)-based polyurethane (PU) dispersion and aqueous polyethyleneimine (PEI) solution without any other chemicals and apparatus (e.g., UV light). In the approach, nontoxic CO in air is used as a selective trigger for the hydrogel formation. CO adsorption onto PEI results in the formation of ammonium cations in PEI and the subsequent multiple ionic crosslinking between PU and PEI chains. Besides the amount of CO in air, the rate of hydrogel formation can be controlled by NaHCO in the PU-PEI mixture, which serves as a CO supplier. The PU hydrogels exhibit tough and stretchable properties with high tensile strength (2.05 MPa) and elongation at break (438.24%), as well as biocompatibility and biodegradability. In addition, the PU hydrogels exhibit high adhesion strength on skin and injectability due to the in situ formation. It is believed that these PU hydrogels have the ideal features for various future applications, such as tissue adhesion barriers, wound dressing, artificial skin, and injectable fillers.
CO 触发原位水凝胶是由水基聚（己内酯）基聚氨酯（PU）分散体和水性聚乙烯亚胺（PEI）溶液开发而成，无需任何其他化学物质和设备（例如，紫外光）。在该方法中，空气中的无毒 CO 被用作水凝胶形成的选择性触发剂。CO 吸附到 PEI 上导致 PEI 中形成铵阳离子，随后 PU 和 PEI 链之间发生多重离子交联。除了空气中的 CO 量之外，PU-PEI 混合物中的 NaHCO3 还可以控制水凝胶的形成速率，因为 NaHCO3 是 CO 的来源。PU 水凝胶具有坚韧和可拉伸的特性，拉伸强度（2.05 MPa）和断裂伸长率（438.24%）高，同时具有生物相容性和可生物降解性。此外，由于原位形成，PU 水凝胶在皮肤和可注射性方面表现出高附着力。相信这些 PU 水凝胶具有各种未来应用的理想特性，例如组织黏附屏障、伤口敷料、人造皮肤和可注射填充剂。
