既往癌症史对下咽癌患者生存的影响。
Impact of prior cancer history on survival of patients with hypopharyngeal cancer.
机构信息
Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Otorhinolaryngology Head and Neck Surgery, Department of Thyroid Center/Thyroid Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
Cancer Med. 2023 Feb;12(3):2929-2936. doi: 10.1002/cam4.5208. Epub 2022 Sep 4.
BACKGROUND
The impact of prior cancer history on survival of hypopharyngeal cancer patients remains unknown. The present study assessed the impact of prior cancer history on survival of patients with hypopharyngeal cancer.
METHODS
Patients with primary hypopharyngeal cancer diagnosed between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was conducted to balance baseline characteristics. One-to-one PSM, Kaplan-Meier method, and log-rank test were performed for survival analysis.
RESULTS
We included 5017 patients with hypopharyngeal cancer. Prior cancer history had no significant impact on overall survival of hypopharyngeal cancer patients in comparison with those without prior cancer history (p = 0.845, after PSM). Subgroup analysis showed that prior cancer history had no significant effect on overall survival of hypopharyngeal cancer patients.
CONCLUSION
More hypopharyngeal cancer patients with prior cancer history should be considered for clinical trials. However, further prospective studies are needed.
背景
既往癌症史对下咽癌患者生存的影响尚不清楚。本研究评估了既往癌症史对上咽癌患者生存的影响。
方法
从监测、流行病学和最终结果（SEER）数据库中提取了 2004 年至 2015 年间诊断为原发性下咽癌的患者。采用倾向评分匹配（PSM）来平衡基线特征。采用 1:1 PSM、Kaplan-Meier 方法和对数秩检验进行生存分析。
结果
我们纳入了 5017 例下咽癌患者。与无既往癌症史的患者相比，有既往癌症史的患者的总体生存率没有显著差异（p=0.845，PSM 后）。亚组分析显示，既往癌症史对上咽癌患者的总体生存率没有显著影响。
结论
应考虑让更多有既往癌症史的下咽癌患者参加临床试验。然而，还需要进一步的前瞻性研究。
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