Guo Lizhi, Yang Li, Rao Liwei, Luo Fengping, Gao Ningcan, Jia Xiaohua, Yu Bin
School of Education, Tianjin University, Tianjin, China; Institute of Applied Psychology, Tianjin University, Tianjin, China; Laboratory of Suicidology, Tianjin Municipal Education Commission, Tianjin, China; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.
School of Education, Tianjin University, Tianjin, China; Institute of Applied Psychology, Tianjin University, Tianjin, China; Laboratory of Suicidology, Tianjin Municipal Education Commission, Tianjin, China.
Arch Gerontol Geriatr. 2022 Nov-Dec;103:104797. doi: 10.1016/j.archger.2022.104797. Epub 2022 Aug 28.
Objective Most previous studies focusing on the association between depressive symptoms and lung function were conducted in patients with chronic lung diseases. This study aims to investigate the association of depressive symptoms with lung function among general Chinese middle-aged and older adults. Participants This study used data from the China Health and Retirement Longitudinal Study (CHARLS). Analyses were conducted with data from three waves (2011, 2013, and 2015) and restricted to those respondents aged 45 and older. Finally, 9487 individuals [mean age (SD) = 58.47 (9.19); female, 53.1%] were included in analysis. Methods Depressive symptoms were measured by the Chinese version of 10-item Center for Epidemiological Studies Depression Scale (CESD-10). Lung function was assessed by peak expiratory flow (PEF). Two-level linear mixed growth models were used to evaluate the longitudinal association between depressive symptoms and PEF. Results Depressive symptoms were significantly associated with PEF among general middle-aged and older adults (b = -1.85, p < 0.001) after adjusting for multiple confounding factors. A significant interaction between depressive symptoms and gender was found (b = 1.29, p < 0.001). The association between depressive symptoms and PEF was greater for men (b = -2.36, p < 0.001) than for women (b = -1.46, p < 0.001). Conclusions This longitudinal study found that increased depressive symptoms were associated with reduced PEF in middle-aged and older adults in China. Compared with women, men with a higher level of depressive symptoms experienced a greater decrement in PEF. Our findings suggest that it is possible to reduce the effects of PEF by improving psychological health among general middle-aged and older populations.
以往大多数关注抑郁症状与肺功能之间关联的研究是在慢性肺病患者中进行的。本研究旨在调查中国普通中老年人群中抑郁症状与肺功能之间的关联。
本研究使用了中国健康与养老追踪调查（CHARLS）的数据。分析采用了三轮（2011年、2013年和2015年）的数据，并仅限于45岁及以上的受访者。最终，9487人[平均年龄（标准差）=58.47（9.19）；女性占53.1%]纳入分析。
抑郁症状采用中文版10项流行病学研究中心抑郁量表（CESD-10）进行测量。肺功能通过呼气峰值流速（PEF）进行评估。采用二级线性混合增长模型评估抑郁症状与PEF之间的纵向关联。
在调整多个混杂因素后，普通中老年人群中抑郁症状与PEF显著相关（b=-1.85，p<0.001）。发现抑郁症状与性别之间存在显著交互作用（b=1.29，p<0.001）。抑郁症状与PEF之间的关联在男性中（b=-2.36，p<0.001）比在女性中（b=-1.46，p<0.001）更强。
这项纵向研究发现，中国中老年人群中抑郁症状增加与PEF降低有关。与女性相比，抑郁症状水平较高的男性PEF下降幅度更大。我们的研究结果表明，通过改善普通中老年人群的心理健康，有可能减轻PEF下降的影响。
