Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania; Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania; Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
Biomed Pharmacother. 2022 Oct;154:113614. doi: 10.1016/j.biopha.2022.113614. Epub 2022 Sep 1.
Rheumatoid arthritis (RA) is a chronic multifactorial disorder of autoimmune etiology with a complex pathophysiological mechanism that is not yet fully elucidated. RA pharmacotherapy includes active molecules of chemical or biological nature that offer symptomatic relief and a slowing of progression, but still in a context of incurability. Therefore, the development of continuous research and multidisciplinary collaboration is essential. Although the management of RA is a topic of significant scientific relevance, existing bibliometric analyses are insufficient to assess this vast field. Consequently, the present study examines numerous manuscripts indexed in the Web of Science database using the VOSviewer software to provide through statistical interpretation of the data a comprehensive description of RA pharmacotherapy in terms of scientific impact, current state of research, number and frequency of citations, most prolific journals, authors, and countries, along with their relationships and other useful data for the literature search/publication process. Furthermore, the use of bubble maps of term occurrence has applicability in identifying current research trends in the field of RA pharmacotherapy as well as their evolution over the years. The leader in this field in terms of published papers is the United States, and the most prolific journal is Annals of the rheumatic diseases. The global management of RA, which is characterized by extensiveness and depth due to many variables, suggests the need for a conceptual framework based on pharmacotherapy coupled with comprehensive bibliometric studies, and the results may be useful for researchers in setting specific objectives that contribute to improving RA outcomes.
类风湿关节炎（RA）是一种慢性多因素自身免疫性疾病，其发病机制复杂，尚未完全阐明。RA 的药物治疗包括具有化学或生物学性质的活性分子，这些分子可提供症状缓解和减缓疾病进展，但仍处于不可治愈的背景下。因此，需要不断开展研究和多学科合作。虽然 RA 的管理是一个具有重要科学意义的主题，但现有的文献计量分析不足以评估这个广阔的领域。因此，本研究使用 Vosviewer 软件对 Web of Science 数据库中的大量文献进行了分析，通过对数据的统计解释，全面描述了 RA 药物治疗在科学影响力、研究现状、引文数量和频率、最有影响力的期刊、作者和国家及其关系等方面的情况，以及其他有助于文献检索/发表过程的有用数据。此外，术语出现的气泡图的使用在确定 RA 药物治疗领域的当前研究趋势及其多年来的演变方面具有适用性。就发表的论文而言，美国是该领域的领导者，最有影响力的期刊是《风湿病年鉴》。由于存在许多变量，RA 的全球管理具有广泛和深入的特点，这表明需要基于药物治疗的概念框架，并结合全面的文献计量学研究，研究结果可能有助于研究人员设定有助于改善 RA 结果的具体目标。
