Center for the Diagnosis of Diseases of Aquatic Organisms, Marine Sciences Institute, Federal University of Ceará, 60165-081, Fortaleza, CE, Brazil.
Fish Shellfish Immunol. 2022 Oct;129:152-160. doi: 10.1016/j.fsi.2022.08.051. Epub 2022 Sep 1.
Lectins are important pattern recognition receptors (PRRs) and their immunological action is related to the recognition of glycans present in the pathogen cells surface. The lectins described for Litopenaeus vannamei are divided into C-type, L-type and galectin, which are mainly expressed in hepatopancreas and hemocytes. They are involved in several immune response pathways, such as phagocytosis, hemocytes recruitment, prophenoloxidase activation, and gene regulation. Although lectins have multiple immune functions, most experimental challenges focus only on WSSV and Vibrio sp. This article is a detailed review on the role of lectins in L. vannamei immune system, bringing together information on molecular structure, temporal and special expression and immune function, highlighting the wide participation of these molecules in shrimp innate immune system.
凝集素是重要的模式识别受体（PRRs），其免疫学作用与识别病原体细胞表面存在的糖有关。已描述的凡纳滨对虾凝集素有 C 型、L 型和半乳糖凝集素，主要在肝胰腺和血细胞中表达。它们参与多种免疫反应途径，如吞噬作用、血细胞募集、酚氧化酶原激活和基因调控。尽管凝集素有多种免疫功能，但大多数实验挑战仅集中在 WSSV 和弧菌上。本文详细综述了凝集素在凡纳滨对虾免疫系统中的作用，汇集了有关分子结构、时空和特殊表达及免疫功能的信息，突出了这些分子在虾先天免疫系统中的广泛参与。
