含聚维酮碘和过氧化氢的漱口液在 COVID-19 患者中的应用。
Utility of mouth rinses with povidone-iodine and hydrogen peroxide in patients with COVID-19.
机构信息
Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, IDIVAL, Santander, Spain.
Departamento de Medicina Interna, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, IDIVAL, Santander, Spain.
出版信息
Enferm Infecc Microbiol Clin (Engl Ed). 2023 Mar;41(3):173-175. doi: 10.1016/j.eimce.2022.08.003. Epub 2022 Sep 1.
INTRODUCTION
Povidone-iodine and hydrogen peroxide could be effective in against SARS-CoV-2.
METHODS
A "non-interventional trial" in 88 patients (43±17 yrs., 55% men) with SARS-CoV-2 in nasopharyngeal swabs (RT-PCR). 31 received mouth rinses/gargling with povidone-iodine (every 8h, two consecutive days), 17 with mouth rinses/gargling of hydrogen peroxide, and 40 controls. Were repeated PCR in 3, 11 and 17 days.
RESULTS
After intervention the viral load (Log10 copies/ml) remained similar in povidone-iodine (4.3±2.7 copies/ml), hydrogen peroxide (4.6±2.9 copies/ml; p=0.40) and controls (4.4±3.0 copies/ml). The percentage of patients with a negative result in the second PCR was 27% in povidone-iodine group, 23% in hydrogen peroxide and 32% in controls; in the third PCR, 62%, 54% y 58% respectively; and in the fourth PCR, 81%, 75% y 81%.
CONCLUSION
Our results do not support the clinical usefulness of mouth rinses/gargling with povidone-iodine or hydrogen peroxide in patients with COVID-19.
简介
聚维酮碘和过氧化氢可能对 SARS-CoV-2 有效。
方法
对 88 例鼻咽拭子（RT-PCR）中 SARS-CoV-2 的患者进行了一项“非干预性试验”。31 例患者接受聚维酮碘漱口/含漱（每 8 小时一次，连续两天），17 例患者接受过氧化氢漱口/含漱，40 例患者为对照组。在第 3、11 和 17 天重复进行 PCR。
结果
干预后，聚维酮碘组（Log10 拷贝/ml）病毒载量（4.3±2.7 拷贝/ml）、过氧化氢组（4.6±2.9 拷贝/ml；p=0.40）和对照组（4.4±3.0 拷贝/ml）相似。第二次 PCR 结果为阴性的患者百分比，聚维酮碘组为 27%，过氧化氢组为 23%，对照组为 32%；第三次 PCR 时，分别为 62%、54%和 58%；第四次 PCR 时，分别为 81%、75%和 81%。
结论
我们的结果不支持 COVID-19 患者使用聚维酮碘或过氧化氢漱口/含漱的临床应用。
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