Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 410013, Hunan Province, China.
Rev Neurosci. 2022 Sep 6;34(3):275-294. doi: 10.1515/revneuro-2022-0056. Print 2023 Apr 25.
In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has becoming increasingly important. More and more evidences have shown that in pathological conditions, abnormal mitochondrial divisions, especially Drp1-Fis1-mediated divisions, play an important role in the occurrence and development of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, glaucoma, and other neurodegenerative diseases. This review highlights several new mechanisms of physiological fission of mitochondria and the difference/connection of physiological/pathological mitochondrial fission. In addition, we described the relationship between abnormal mitochondrial dynamics and neurodegenerative diseases in detail and emphatically summarized its detection indicators in basic experiments, trying to provide references for further mechanism exploration and therapeutic targets.
近年来，线粒体动力学在神经退行性疾病中的作用变得越来越重要。越来越多的证据表明，在病理条件下，异常的线粒体分裂，特别是 Drp1-Fis1 介导的分裂，在阿尔茨海默病、帕金森病、肌萎缩侧索硬化症、亨廷顿病、青光眼等神经退行性疾病的发生和发展中起着重要作用。本综述强调了线粒体生理分裂的几个新机制，以及生理/病理性线粒体分裂的区别/联系。此外，我们详细描述了异常线粒体动力学与神经退行性疾病之间的关系，并着重总结了其在基础实验中的检测指标，试图为进一步的机制探索和治疗靶点提供参考。
