Hardenbergh Dylan, Molina Emily, Naik Rakhi, Geetha Duvuru, Chaturvedi Shruti, Timlin Homa
21611Columbia University Medical Center, New York, NY, USA.
1501Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lupus. 2022 Oct;31(11):1285-1295. doi: 10.1177/09612033221122163. Epub 2022 Sep 3.
Patients with systemic lupus erythematosus (SLE) are at an elevated risk for certain cancers compared to the population at large. Cancers seen at higher rates in the SLE population include hematologic malignancies, such as non-Hodgkin lymphoma, and cancers of the lung and thyroid. SLE patients also have a decreased risk for certain malignancies, such as breast cancer, melanoma, and prostate cancer. We review the literature on risk factors for malignancy in patients with SLE and discuss the exogenous and innate factors that are thought to contribute to the unique pattern of cancer risk observed in this patient population. These risk factors are important for providers of SLE patients to understand in order to maintain high clinical suspicion and detect malignancy as soon as possible. Further research is needed to determine the most effective guidelines on counseling patients on cancer screening and prevention.
与普通人群相比，系统性红斑狼疮（SLE）患者患某些癌症的风险更高。SLE人群中发病率较高的癌症包括血液系统恶性肿瘤，如非霍奇金淋巴瘤，以及肺癌和甲状腺癌。SLE患者患某些恶性肿瘤的风险也较低，如乳腺癌、黑色素瘤和前列腺癌。我们回顾了关于SLE患者恶性肿瘤危险因素的文献，并讨论了被认为导致该患者群体中观察到的独特癌症风险模式的外源性和内在因素。这些危险因素对于SLE患者的医疗服务提供者来说很重要，以便保持高度的临床怀疑并尽快发现恶性肿瘤。需要进一步研究以确定关于为患者提供癌症筛查和预防咨询的最有效指南。
