Xu Wei, Yang Ludi, Ge Shengfang, Jia Shichong, Gu Fen
Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China.
Front Oncol. 2022 Aug 18;12:960494. doi: 10.3389/fonc.2022.960494. eCollection 2022.
Conjunctival melanoma (CM) is a life-threatening ocular tumor with a high rate of local recurrence and metastasis. Our objective is to analyze research trends in CM field and compare contributions from different countries, institutions and authors.
We extracted all CM-related publications published from 1997 to 2022 from the Web of Science database and applied Microsoft Excel and VOSviewer to review publication data, analyze publication trends, and visualize relevant data.
A total of 708 publications were identified. The United States contributed the most publications (280) and citations (8,781 times) with the highest H-index value (47). The , , and were the most productive journal concerning CM, and Shields CL, Shields JA, Jager MJ as well as Finger PT had published the most papers in the field. Keywords were classified into three clusters: clinical research, management-related research and genetic research. The keywords "primary acquired melanosis", "metastasis" and " mutations" were most frequently emerged. According to the average appearing year (AAY), targeted therapy (AAY of 2019.0) and nivolumab (AAY of 2018.7) were identified as the main focuses of the field in the near future.
In the past 25 years, the United States, Germany, England and the Netherlands held the leading position in the CM research. A group of scholars made important contributions to CM research and will continue to guide cutting-edge research. Treatments that have been shown to be effective for advanced cutaneous melanoma, such as targeted therapy and immunotherapy, are potential focuses for future CM research.
结膜黑色素瘤(CM)是一种危及生命的眼部肿瘤,局部复发和转移率很高。我们的目的是分析CM领域的研究趋势,并比较不同国家、机构和作者的贡献。
我们从Web of Science数据库中提取了1997年至2022年发表的所有与CM相关的出版物,并应用Microsoft Excel和VOSviewer来审查出版数据、分析出版趋势并可视化相关数据。
共识别出708篇出版物。美国的出版物数量(280篇)和被引次数(8781次)最多,H指数值最高(47)。《 》《 》《 》和《 》是关于CM的发文量最多的期刊,Shields CL、Shields JA、Jager MJ以及Finger PT在该领域发表的论文最多。关键词被分为三个聚类:临床研究、管理相关研究和基因研究。“原发性获得性黑色素沉着症”“转移”和“ 突变”等关键词出现频率最高。根据平均出现年份(AAY),靶向治疗(AAY为2019.0)和纳武单抗(AAY为2018.7)被确定为该领域近期的主要研究重点。
在过去25年中,美国、德国、英国和荷兰在CM研究中占据领先地位。一批学者为CM研究做出了重要贡献,并将继续引领前沿研究。对晚期皮肤黑色素瘤已显示出疗效的治疗方法,如靶向治疗和免疫治疗,是未来CM研究的潜在重点。