Cheng Xiuli, Hu Jin, Liu Xiaofeng, Tibenda Jonnea Japhet, Wang Xiaobo, Zhao Qipeng
Department of Pharmacy, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China.
Department of Preparation Center, General Hospital of Ningxia Medical University, Yinchuan, China.
Front Pharmacol. 2022 Aug 19;13:934256. doi: 10.3389/fphar.2022.934256. eCollection 2022.
Traditional Chinese medicine (TCM) has a significant role in treating and preventing human diseases. Ischemic heart and cerebrovascular injuries are two types of diseases with different clinical manifestations with high prevalence and incidence. In recent years, it has been reported that many TCM has beneficial effects on ischemic diseases through the inhibition of apoptosis, which is the key target to treat myocardial and cerebral ischemia. This review provides a comprehensive summary of the mechanisms of various TCMs in treating ischemic cardiovascular and cerebrovascular diseases through anti-apoptotic targets and pathways. However, clinical investigations into elucidating the pharmacodynamic ingredients of TCM are still lacking, which should be further demystified in the future. Overall, the inhibition of apoptosis by TCM may be an effective strategy for treating ischemic cardio-cerebrovascular diseases.
中医在治疗和预防人类疾病方面发挥着重要作用。缺血性心脑血管损伤是两种具有不同临床表现、高患病率和发病率的疾病。近年来，有报道称许多中药通过抑制细胞凋亡对缺血性疾病具有有益作用，而细胞凋亡是治疗心肌和脑缺血的关键靶点。本综述全面总结了各种中药通过抗凋亡靶点和途径治疗缺血性心脑血管疾病的机制。然而，目前仍缺乏阐明中药药效成分的临床研究，未来应进一步揭开其神秘面纱。总体而言，中药抑制细胞凋亡可能是治疗缺血性心脑血管疾病的有效策略。
