Liu Kuo, Liu Demin, Cui Wei
Cardiology Department, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Evid Based Complement Alternat Med. 2022 Mar 31;2022:6121407. doi: 10.1155/2022/6121407. eCollection 2022.
After acute myocardial infarction, early restoration of myocardial perfusion by thrombolysis or percutaneous coronary intervention is the most effective way to reduce the size of myocardial infarction and improve clinical outcomes. However, recovery of blood flow to the ischemic myocardium may cause ischemia-reperfusion (I/R) injury, a phenomenon that instead reduces the efficacy of myocardial reperfusion. Traditional Chinese medicine (TCM) has long been used for the treatment of cardiovascular diseases and has shown remarkable efficacy. Many studies have shown that some TCMs and their active components can exert protective effects against myocardial I/R injury through different mechanisms. This review summarized the protective mechanisms and current research advances of TCMs in myocardial I/R injury.
急性心肌梗死后，通过溶栓或经皮冠状动脉介入治疗早期恢复心肌灌注是缩小心肌梗死面积和改善临床结局的最有效方法。然而，缺血心肌恢复血流可能会导致缺血再灌注（I/R）损伤，这种现象反而会降低心肌再灌注的疗效。中医长期以来一直用于治疗心血管疾病，并已显示出显著疗效。许多研究表明，一些中药及其活性成分可通过不同机制对心肌I/R损伤发挥保护作用。本综述总结了中药在心肌I/R损伤中的保护机制及当前研究进展。
