Yatani R, Kusano I, Shiraishi T, Miura S, Takanari H, Liu P I
Ann Clin Lab Sci. 1987 May-Jun;17(3):178-82.
To evaluate a possible correlation between tissue hormone levels and the development of latent prostatic carcinoma, levels of testosterone, estradiol, and prolactin were measured in homogenates of prostates by radioimmunoassay. One hundred and thirteen prostates obtained at autopsy from males over age 50 were morphologically classified into three groups; benign prostates, prostates with latent well differentiated type carcinoma (LWTC), and prostates with latent moderately or poorly differentiated type carcinoma (LMPTC). As detected by double antibody radioimmunoassay, tissue prolactin levels were statistically elevated (P less than 0.05) in prostates classified as LMPTC compared to benign prostates only. No statistical differences were noted for prostatic tissue levels for testosterone and estradiol in the three groups. Results suggest the possibility that prolactin may relate to the promotion and/or manifestation of prostatic carcinoma at the tissue level.
为评估组织激素水平与潜伏性前列腺癌发生之间的可能关联，采用放射免疫分析法测定了前列腺匀浆中睾酮、雌二醇和催乳素的水平。从50岁以上男性尸检获取的113个前列腺在形态学上分为三组：良性前列腺、潜伏性高分化型癌（LWTC）前列腺和潜伏性中分化或低分化型癌（LMPTC）前列腺。通过双抗体放射免疫分析法检测发现，与仅良性前列腺相比，分类为LMPTC的前列腺组织催乳素水平有统计学意义的升高（P小于0.05）。三组中前列腺组织睾酮和雌二醇水平未观察到统计学差异。结果提示催乳素可能在组织水平上与前列腺癌的进展和/或表现有关。
