Yang Chim M
Otolaryngology - Head and Neck Surgery, Western Reserve Hospital, Cuyahoga Falls, USA.
Cureus. 2022 Jul 31;14(7):e27504. doi: 10.7759/cureus.27504. eCollection 2022 Jul.
Multiple endocrine neoplasia type 2 is an autosomal dominant neoplastic syndrome with subtypes multiple endocrine neoplasia type 2A, multiple endocrine neoplasia type 2B, and familial medullary thyroid carcinoma. Medullary thyroid carcinoma universally coincides with multiple endocrine neoplasia type 2. Multiple endocrine neoplasia type 2A is a rare disease and the affected patients are generally asymptomatic. The morbidity and mortality are mainly due to medullary thyroid carcinoma and often proper clinical workup is warranted for expedited surgical intervention. Total thyroidectomy along with neck dissection may be required for disease control. This report will cover a patient who presented with medullary thyroid carcinoma and was worked up to have multiple endocrine neoplasia type 2A. She underwent total thyroidectomy with central neck dissection.
2型多发性内分泌腺瘤病是一种常染色体显性肿瘤综合征，包括2A型多发性内分泌腺瘤病、2B型多发性内分泌腺瘤病和家族性甲状腺髓样癌等亚型。甲状腺髓样癌普遍与2型多发性内分泌腺瘤病同时存在。2A型多发性内分泌腺瘤病是一种罕见疾病，患病患者通常没有症状。发病率和死亡率主要归因于甲状腺髓样癌，因此常常需要进行适当的临床检查以便尽快进行手术干预。为控制病情，可能需要进行全甲状腺切除术及颈部淋巴结清扫术。本报告将涵盖一名患有甲状腺髓样癌且经检查确诊为2A型多发性内分泌腺瘤病的患者。她接受了全甲状腺切除术及中央区颈部淋巴结清扫术。
