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合成2-氨基噻吩的绿色方法

Green methodologies for the synthesis of 2-aminothiophene.

作者信息

Duvauchelle Valentin, Meffre Patrick, Benfodda Zohra

机构信息

CHROME Laboratory, University of Nîmes, Rue du Dr. G. Salan, 30021 Nîmes Cedex 1, France.

出版信息

Environ Chem Lett. 2023;21(1):597-621. doi: 10.1007/s10311-022-01482-1. Epub 2022 Aug 29.

DOI:10.1007/s10311-022-01482-1
PMID:36060495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9421116/
Abstract

Pollution and the rising energy demand have prompted the design of new synthetic reactions that meet the principles of green chemistry. In particular, alternative synthesis of 2-aminothiophene have recently focused interest because 2-aminothiophene is a unique 5-membered S-heterocycle and a pharmacophore providing antiprotozoal, antiproliferative, antiviral, antibacterial or antifungal properties. Here, we review new synthetic routes to 2-aminothiophenes, including multicomponent reactions, homogeneously- or heterogeneously-catalyzed reactions, with focus on green pathways.

摘要

污染和不断增长的能源需求促使人们设计符合绿色化学原则的新合成反应。特别是，2-氨基噻吩的替代合成最近引起了关注，因为2-氨基噻吩是一种独特的五元含硫杂环，也是一种具有抗原生动物、抗增殖、抗病毒、抗菌或抗真菌特性的药效基团。在此，我们综述了2-氨基噻吩的新合成路线，包括多组分反应、均相或非均相催化反应，重点关注绿色合成途径。

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