Department of Geriatrics, Dadukou District People's Hospital, Chongqing 400084, China.
Comput Math Methods Med. 2022 Aug 26;2022:8332278. doi: 10.1155/2022/8332278. eCollection 2022.
Patients with type 2 diabetes have twice as much of the risk of acute ischemic stroke (AIS) occurrence as healthy individuals, and the AIS patients with type 2 diabetes have a higher risk of death and a poorer prognosis. This study was to investigate the interrelationship between hyperglycemia and AIS and provided a reference for blood glucose management of AIS patients. The blood glucose level of AIS patients of the present study was controlled by insulin below 180 mg/dL (standard group) and between 80 and 130 mg/dL (management group). And the fasting venous blood samples were collected for determination of blood glucose level, homeostasis model assessment of insulin resistance (HOMA-IR), peptide C, and basal insulin level. Furthermore, lipids of the blood samples were detected using metabolomics, so as to clarify the similarities and differences in metabolic patterns in AIS patients with diabetes after the intervention of different glycemic strategies. The results revealed that compared to the standard group, the blood glucose level and HOMA-IR in the management group were significantly decreased, and levels of peptide C and basal insulin level were greatly increased. Through lipidomics detection, 83, 50, and 44 types of significantly upregulated differential lipids were detected in the standard vs. normal groups, the standard vs. management groups, and the management vs. normal groups, respectively, with triacylglycerol dominated. This study preliminarily revealed metabolic differences among AIS patients with hyperglycemia after different blood glucose intervention methods, hoping to provide a theoretical basis for clinical prevention and treatment of this disease.
2 型糖尿病患者发生急性缺血性脑卒中（AIS）的风险是健康人群的两倍，且合并 2 型糖尿病的 AIS 患者死亡风险更高、预后更差。本研究旨在探讨高血糖与 AIS 的相互关系，为 AIS 患者的血糖管理提供参考。本研究通过胰岛素将 AIS 患者的血糖水平控制在 180mg/dL 以下（标准组）和 80~130mg/dL 之间（管理组）。采集空腹静脉血样，测定血糖、胰岛素抵抗指数（HOMA-IR）、肽 C 和基础胰岛素水平。此外，采用代谢组学检测血液样本中的脂质，以阐明不同血糖控制策略干预后糖尿病 AIS 患者代谢模式的异同。结果表明，与标准组相比，管理组的血糖水平和 HOMA-IR 显著降低，肽 C 和基础胰岛素水平显著升高。通过脂质组学检测，在标准组与正常组、标准组与管理组、管理组与正常组之间分别检测到 83、50 和 44 种显著上调的差异脂质，均以三酰甘油为主。本研究初步揭示了不同血糖干预方法后高血糖 AIS 患者的代谢差异，有望为该疾病的临床防治提供理论依据。
