The Second Clinical Medical College of Fujian Medical University, Quanzhou, China.
Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Front Endocrinol (Lausanne). 2022 Aug 18;13:976465. doi: 10.3389/fendo.2022.976465. eCollection 2022.
Type 2 diabetes mellitus(T2DM) is regarded as one of the most severe chronic metabolic diseases worldwide, which poses a great threat to human safety and health. The main feature of T2DM is the deterioration of pancreatic beta-cell function. More and more studies have shown that the decline of pancreatic beta-cell function in T2DM can be attributable to beta-cell apoptosis, but the exact mechanisms of beta-cell apoptosis in T2DM are not yet fully clarified. Therefore, in this review, we will focus on the current status and progress of research on the mechanism of pancreatic beta-cell apoptosis in T2DM, to provide new ideas for T2DM treatment strategies.
2 型糖尿病（T2DM）被认为是全球最严重的慢性代谢疾病之一，对人类安全和健康构成了极大威胁。T2DM 的主要特征是胰腺β细胞功能恶化。越来越多的研究表明，T2DM 中胰腺β细胞功能的下降可归因于β细胞凋亡，但 T2DM 中β细胞凋亡的确切机制尚不完全清楚。因此，在这篇综述中，我们将重点介绍 T2DM 中胰腺β细胞凋亡机制的研究现状和进展，为 T2DM 治疗策略提供新的思路。
