Honda H, Agishi T, Oba S, Nakagawa Y, Kihara K, Huchinoue S, Nakazawa H, Teraoka S, Ota K
Gan To Kagaku Ryoho. 1987 Jul;14(7):2359-64.
Thirty cancer patients, who were diagnosed to be beyond the operable stage, were treated by intra-arterial anticancer agent infusion via an implantable vascular access device (VAD) combined with local hyperthermia and/or charcoal hemoperfusion. The VAD was implanted by a surgical procedure in 14 patients, or by a technique similar to super-selective angiography mainly via the femoral artery in the remaining 16 patients who could not be operated on because of their seriously severe clinical condition and/or the difficulty involved in approaching the tumor feeding artery due to the presence of huge tumors or multiple lymph node metastasis. No serious complications were seen in these treatments. However, the catheter became occluded after an average post-implantation period of 9 months in 6 patients in the operative group. Since an operative procedure is very often too invasive for end-stage cancer patients and may enhance tumor growth, VAD implantation utilizing an angiographic technique is recommendable for the treatment of advanced cancer.
30例被诊断为已超出可手术阶段的癌症患者，通过植入式血管通路装置（VAD）进行动脉内抗癌药物灌注，并结合局部热疗和/或血液灌流进行治疗。14例患者通过外科手术植入VAD，其余16例因临床状况严重和/或因存在巨大肿瘤或多处淋巴结转移而难以接近肿瘤供血动脉，无法进行手术的患者，则通过主要经股动脉的类似超选择性血管造影技术植入VAD。这些治疗中未观察到严重并发症。然而，手术组6例患者在植入VAD后平均9个月导管发生堵塞。由于手术操作对终末期癌症患者往往侵袭性过大，且可能促进肿瘤生长，因此推荐采用血管造影技术植入VAD来治疗晚期癌症。
